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NCT Number: NCT07569289

Triggering Oocyte Maturation in POSEIDON Group 3 and 4 Poor Responders Using Double Trigger or HCG Trigger

The aim of this randomized controlled study is to compare the efficacy of double trigger protocol [ the co-administration of GnRH agonist with HCG ( 38 - 39 and 35 - 36 h prior to ovum pick-up, respectively ] with HCG in triggering ovulation in patients with expected poor response to ovarian stimulation

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

18 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 2

Primary location

Bedaya Hospital

Giza, Giza Governorate, 3753303, Egypt

Location contact

Reham Elkhalifa, M.D, PhD

PRINCIPAL_INVESTIGATOR

Usama M Fouda, Prof

CONTACT

[email protected]

+201095401375

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • POSEIDON group 3 and 4
  • GnRH antagonist IVF cycle

Exclusion criteria

  • Hypogonadotrophic hypogonadism
  • Endometriosis
  • History of recurrent abortion

Treatment and study plan

Double trigger

Drug

Triptorelin (0.2 mg/S.C ) and HCG (10000 IU/I.M) are administered 38 to 39 h and 35 to 36 h prior to ovum pick-up., respectively.

HCG trigger

Drug

HCG (10000 IU/I.M) is administered 35 to 36 h prior to ovum pick-up.

Primary outcomes

  1. Metaphase-II oocytes rate

    Time frame: Ten to fifteen days after starting ovarian stimulation

    Number of MII oocyte/ number of cumulus oocyte complex

Secondary outcomes

  1. Clinical pregnancy rate

    Time frame: Five weeks after embryo transfer

    Presence of intrauterine gestational sac detected by transvaginal ultrasound

  2. Ongoing pregnancy Rate

    Time frame: Eighteen weeks after embryo transfer

    Pregnancies continued beyond 20 weeks gestation

Study contacts

Contact information is provided by the study sponsor or research team.

Usama M Fouda, Prof.

CONTACT

[email protected]

+201095401375

Sponsors and collaborators

Lead sponsor

Bedaya Hospital

Other

Registry information

Official study title

Triggering Oocyte Maturation in POSEIDON Group 3 and 4 Poor Responders Using Double Trigger or HCG Trigger . A Randomized Controlled Study

Important dates

Study start
2026
Primary completion
2027
Study completion
2028
First posted
May 6, 2026
Registry last updated
May 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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