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OpenTrials
Completed

NCT Number: NCT02916173

Triggering of Follicular Maturation

The follicular phase of the menstrual cycle involves the hourly release of gonadotropin-releasing hormone, which binds to receptors on the gonadotropes. This results in the secretion of follicle stimulating hormone and luteinizing hormone in hourly pulses that regulate follicular growth. At midcycle, rapidly rising estradiol from the dominant follicle and a small rise in progesterone lead to a gonadotrophic surge. An increase in the amplitude of Luteinizing hormone and Follicle stimulating hormone pulses initiates oocyte maturity and triggers ovulation approximately

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Key information

Conditions

Increase Pregnancy Rate

Age range

20 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 3

Primary location

Ahmed Abbas

Assiut, Cairo Governorate, 002, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Infertile couples wishing to do intracytoplasmic injection trial .
  • first intracytoplasmic injection trial
  • Body mass index:18-30.

5-Antral follicular count: more than 5 follicles in one ovary 6-normal, mild or moderate male factor infertility. 7- Antimullerian hormone >1 ng/ml

Exclusion criteria

  • Azoospermic male.
  • Body mass index more than 29.
  • Patients with endometriosis .
  • Antimullerian hormone < 1 ng/ml

Treatment and study plan

Recombinant Human Chorionic Gonadotrophin

Drug

250 unit intramuscular

Other names: Ovitrelle

human chorionic gonadotrophin + gonadotrophin releasing hormone agonist

Drug

250 unit intramuscular + 1 mg subcutaneous

Primary outcomes

  1. Number of M II oocytes in both groups

    Time frame: 24 hours

Secondary outcomes

  1. Fertilization rate in each group

    Time frame: 3 days

  2. Clinical pregnancy rate in each group

    Time frame: 15 days

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Triggering of Follicular Maturation Using Human Chorionic Gonadotrophin With Gonadotrophin Releasing Hormone Agonist Versus Human Chorionic Gonadotrophin Alone in Antagonist Protocol in Assisted Reproductive Technology : a Randomized Controlled Trial

Important dates

Study start
2016
Primary completion
2018
Study completion
2019
First posted
Sep 27, 2016
Registry last updated
Mar 20, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.