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OpenTrials
Completed

NCT Number: NCT00627406

Triggering of Final Oocyte Maturation With GnRHa (Buserelin) in GnRH Antagonist Cycles

The purpose of this study is to possibly further improve the clinical outcome and explore the incidence of OHSS in patients, who have final oocyte maturation with GnRHa (Buserelin) in GnRH antagonist IVF/ICSI cycles

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Key information

Conditions

OHSS (Ovarian Hyperstimulation) Adnexal Diseases Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Gonadal Disorders Ovarian Diseases Ovarian Hyperstimulation Syndrome Urogenital Diseases

Age range

20 year–39 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

The Fertility Clinic, Regional Hospital of Skive

Skive, 7800, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient complying with the conditions for IVF or ICSI treatment
  • Female age over 20 years and under 40 years
  • Normal regular cycle and patients with oligomenorrhea
  • BMI > 18 and < 35
  • each patient contributes with one cycle only

Exclusion criteria

  • Significant disturbances in the woman (diabetes, epilepsy, liver/renal/heart disease, metabolic disorder)
  • Patients with > 25 follicles on the day of triggering ovulation

Treatment and study plan

Buserelin and Pregnyl

Drug

Subcutaneous injection 0.5 mg and 1500 IU

pregnyl

Drug

Subcutaneous injection 5000 IU

Primary outcomes

  1. Frequency of Moderate to Severe OHSS.

    Time frame: From the date of triggering ovulation until 2 weeks after pregnancy test. group C and D. 12 days after pregnancy test

Secondary outcomes

  1. Pregnancy Rate

    Time frame: from stimulation day 1 until last ultrasound scan 7 weeks after a positive pregnancy test

Sponsors and collaborators

Lead sponsor

Regionshospitalet Viborg, Skive

Other

Registry information

Official study title

A Prospective Randomised Study to Evaluate the Effect of Triggering Ovulation With GnRHa (Buserelin) and Low Dose hCG (Pregnyl) as Compared to the Use of Conventional Doses of hCG (Pregnyl)

Important dates

Study start
2009
Primary completion
2011
Study completion
2011
First posted
Mar 3, 2008
Registry last updated
Nov 27, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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