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NCT Number: NCT05269472

Trigeminal Neuralgia Electrophysiology

The study intervention is to perform standard somatosensory evoked responses limited to the face during rhizotomy procedures of the gasserian ganglion (trigeminal ganglion) for the treatment of trigeminal neuralgia. The evoked responses will be measured at two locations before and after the clinical rhizotomy including: the standard contralateral scalp (EEG) and at the gasserian ganglion through an FDA-approved recording electrode.

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Key information

Conditions

Trigeminal Neuralgia Cranial Nerve Diseases Facial Nerve Diseases Facial Neuralgia Mouth Diseases Nervous System Diseases Stomatognathic Diseases Trigeminal Nerve Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Minnesota

Minneapolis, Minnesota, 55455, United States

Location status: Recruiting

Location contact

Matthew Maple

CONTACT

[email protected]

612-946-1424

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

(TGN):

  • Adults of 18 years or older
  • Scheduled to undergo percutaneous rhizotomy for facial pain

Exclusion criteria

(TGN):

  • Facial pain of unclear origin (i.e. not clearly TGN pain)
  • Rhizotomy procedure canceled

Inclusion criteria

(Healthy controls)

  • Adults of 18 years or older

Exclusion criteria

(Healthy Controls)

  • Diagnosis or history of facial pain such as TMD or TGN
  • History of migraine
  • History of any functional pain disorder: fibromyalgia, IBS, CRPS
  • Recent chronic pain (within last month)
  • Unwilling to participate for two hours in lab
  • Current acute pain

Treatment and study plan

Trigeminal Electrophysiology

Procedure

This study will pilot and test the feasibility of introducing electrophysiology into the routine rhizotomy procedure by including trigeminal somatosensory evoked potentials (TSEPs) and recording from electrodes at the level of the ganglion.

Primary outcomes

  1. Determine the feasibility of measuring trigeminal somatosensory evoked potentials to improve personalized mapping during percutaneous rhizotomy

    Time frame: 3 years

    percentage of consented participants who complete the study

Study contacts

Contact information is provided by the study sponsor or research team.

Matthew Maple

CONTACT

[email protected]

612-946-1424

Sponsors and collaborators

Lead sponsor

University of Minnesota

Other

Registry information

Official study title

Trigeminal Evoked Responses to Improve Rhizotomy

Important dates

Study start
2022
Primary completion
2027
Study completion
2027
First posted
Mar 8, 2022
Registry last updated
Nov 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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