Tricuspid RegurgitAtion rIsk modeL Study (TRAIL Study)

This study is a multicenter cohort study including patients diagnosed with tricuspid regurgitation during hospitalization. The primary outcome of the study is all-cause death, and the secondary outcome is cardiovascular events. The prognostic risk factors of patients with tricuspid regurgitation are evaluated, and the prognostic models are constructed through the follow-up observation.

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Key information

Conditions

Tricuspid Regurgitation Cardiovascular Diseases Heart Diseases Heart Valve Diseases Tricuspid Valve Insufficiency

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The First Affiliated Hospital of Sun Yat-sen Univerity, Guangzhou, Guangdong, China

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Aged over 18 yrs.
Patients diagnosed with tricuspid regurgitation during hospitalization.

Exclusion criteria

Patients unable to provide informed consent.

Treatment and study plan

Primary outcomes

all-cause mortality

Time frame: Through study completion, an average of 5 years

Death due to any cause after enrollment

Secondary outcomes

Cardiovascular death

Time frame: Through study completion, an average of 5 years

Death caused by cardiac causes
Heart Failure Hospitalization

Time frame: Through study completion, an average of 5 years

Hospitalization with the primary reason for admission as acute decompensated HF and administration of intravenous or mechanical heart failure therapies.

Study contacts

Contact information is provided by the study sponsor or research team.

Xiaodong Zhuang

CONTACT

[email protected]

+8613760755035

Sponsors and collaborators

Lead sponsor

Sun Yat-sen University

Other

Collaborators

Affiliated Hospital of Guangdong Medical University
Eighth Affiliated Hospital, Sun Yat-sen University
First Affiliated Hospital, Sun Yat-Sen University
Jieyang People's Hospital
Second Affiliated Hospital of Shantou University Medical College
Third Affiliated Hospital, Sun Yat-Sen University
Zhongshan People's Hospital, Guangdong, China

Registry information

Important dates

Study start: 2016
Primary completion: 2030
Study completion: 2030
First posted: Apr 15, 2025
Registry last updated: Apr 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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