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OpenTrials
Completed

NCT Number: NCT01292343

Triclosan Toothpaste and Third Molar Surgery

Triclosan containing dentifrices are effective in the prevention of inflammatory complications following third molar surgery through reducing preoperative oral bacteria load.

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Key information

Conditions

Dry Socket Infections Mouth Diseases Stomatognathic Diseases Wound Infection

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Rochester Eastman Dental Center

Rochester, New York, 14620, United States

About this study

This study may provide evidence on the effect of triclosan containing dentifrice on oral bacteria and oral inflammation prior to third molar surgery, and on the incidence of inflammatory complications after the surgery. If proven effective, dentifrice containing triclosan may be recommended prior to tooth extractions and replace antibiotics and other antimicrobial products as a prophylactic procedure before oral surgery procedures.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • must include at least one mandibular third molar with partial or full bony impaction
  • no sign of active pericoronal (around the crown) infections
  • must have not taken antibiotics for any reason in the past 30 days
  • must be healthy and between 18 and 35 years of age
  • must be able to read and sign an informed consent

Exclusion criteria

  • Subjects with systemic diseases and pregnant or lactating women
  • Subjects with advanced periodontal diseases or having two or more untreated caries lesions
  • Subjects who cannot read and sign an informed consent
  • Subjects with signs of pericoronal infections

Treatment and study plan

Colgate Total Toothpaste

Other

Toothbrushing with Colgate Total Toothpaste

Other names: triclosan, dentifrice

Colgate Regular Toothpaste

Other

Toothbrushing with Colgate regular toothpaste

Other names: fluoride, dentifrice

Primary outcomes

  1. dry socket

    Time frame: 3 to 7 days

    Development of dry socket (alveolar osteitis) 3 to 7 days after tooth extraction

Secondary outcomes

  1. wound infection

    Time frame: 3 to 7 days

    Development of tooth extraction wound infection 3 to 7 days after extraction

Sponsors and collaborators

Lead sponsor

University of Rochester

Other

Registry information

Official study title

Effect of a Triclosan Containing Dentifrice on Oral Bacteria and Postoperative Complications Following Third Molar Surgery

Important dates

Study start
2008
Primary completion
2013
Study completion
2013
First posted
Feb 9, 2011
Registry last updated
Oct 28, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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