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Completed

NCT Number: NCT04159220

Trial to Evaluate an Optimization Procedure of Alveolar Recruitment During Transport Performed by Nurse Anesthetists in Intensive Care

Intra hospital transport of ICU patients is still at high risk of respiratory complications.We propose to determine if endotracheal tube clamping prior to disconnect ventilator allows to avoid oxygenation decrease.

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Key information

Conditions

Respiratory Complication

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Departement d'anesthésie et réanimation Gui de Chauliac (DAR C)

Montpellier, 34295, France

About this study

Changing respiratory support and multiples endotracheal tube disconnections may induce a loss of PEEP and finally lead to alveolar derecruitment. This study is an evaluation of a care procedure to limit the incidence of alveolar derecruitment in ventilated intubated ICU patients during transport for CT scan.

Intra hospital transport of ICU patients are performed by anesthesiologist nurses, the physician entrusts them this activity.

This is a randomized controlled study, the procedure is to clamp endotracheal tube before each disconnection from ventilator.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • intensive care patient
  • intubated, sedated, controlled assisted ventilation
  • Intra hospital transport for CT scan
  • arterial catheter
  • the patient or his trusted person consent to the study

Exclusion criteria

  • Patient Covid tests positive or Covid test results not received
  • extubated, unsedated,
  • reinforced tube
  • tracheotomy
  • pregnancy
  • guardianship

Treatment and study plan

Clamping of the ventilator endotracheal tube

Procedure

The transport will be released in accordance with SFAR SRLF guideline. Before each disconnection from ventilator endotracheal tube will be clamped.

Primary outcomes

  1. Measure of the pa02/Fi02

    Time frame: 1 hour after the end of the transport

    Evaluate the effectiveness of a procedure to avoid alveolar delisting, measured by the absence of a decrease in the PaO2/FiO2 ratio (before transport and 1 hour after return to bed) during an HIT performed by a nurse anaesthetist/caregiver team, of intubated and ventilated resuscitation patients in a controlled assisted volume.

Secondary outcomes

  1. Assessment of the pa02

    Time frame: 1 hour after the end of the HIT

    Evaluate the impact of the procedure on the absence of PaO2 reduction (before transport and 1 hour after return to bed)

  2. Assessment of the pa02

    Time frame: immediately after the end of the HIT

    Evaluate the effectiveness of the procedure on Pa02 immediately after reconnection to the heavy resuscitation ventilator

  3. Assessment of the pa02

    Time frame: 6 hours after the end of of the HIT

    Evaluate the effectiveness of the procedure on Pa02 immediately after reconnection to the heavy resuscitation ventilator

  4. length of stay

    Time frame: up to 28 days

    Evaluate the impact of the intervention on the length of ICU stay

  5. duration of invasive ventilation

    Time frame: up to 28 days

    Evaluate the impact of the intervention on the invasive ventilation

  6. occurrence of adverse events during the HIT

    Time frame: immediately after the end of the HIT

    occurrence of adverse events related to the clamping

Sponsors and collaborators

Lead sponsor

University Hospital, Montpellier

Other

Registry information

Official study title

Randomized Controlled Trial to Evaluate an Optimization Procedure of Alveolar Recruitment During Transport Performed by Nurse Anesthetists in Intensive Care

Acronym: ESCORTE

Important dates

Study start
2020
Primary completion
2023
Study completion
2023
First posted
Nov 12, 2019
Registry last updated
May 31, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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