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NCT Number: NCT00183742

Trial of Liposomal Doxorubicin (Doxil) and Weekly Docetaxel (Taxotere)

This study is for patients with advanced cancer that has failed treatment with conventional therapy or for which no standard treatment exists. The purpose of this study is to determine the highest dose that can be given of 2 chemotherapy drugs, docetaxel (also called Taxotere) and liposomal doxorubicin (also called Doxil), when given together and to determine the side effects of this combination. Both Taxotere and Doxil are chemotherapy drugs that can decrease the size of several different tumors. Taxotere is approved by the Food and Drug Administration (FDA) for the treatment of breast and lung cancers, and Doxil is approved for the treatment of ovarian cancer.

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Key information

Conditions

Cancer Carcinoma Neoplasms Neoplasms by Histologic Type Neoplasms, Glandular and Epithelial

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

U.S.C./Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Histological proof of advanced or recurrent solid tumor which has failed prior therapy, or for which no effective therapy is available.
  • Ovarian cancer patients (or primary peritoneal carcinoma) whose only manifestation of disease is an elevated cancer antigen (CA) 125 of > 100 are eligible.
  • SWOG performance status 0-2.
  • Absolute granulocyte count (AGC) greater than or equal to 1.5; platelets greater than or equal to 100,000.
  • Total bilirubin less than or equal to the upper limit of normal (ULN).
  • Transaminases (SGOT and/or SGPT) may be up to 2.5 x institutional upper limit of normal (ULN) if alkaline phosphatase is <= ULN, or alkaline phosphatase may be up to 4 x ULN if transaminases are <= ULN. However, patients who have both transaminase elevation > 1.5 x ULN and alkaline phosphatase > 2.5 x ULN are not eligible for this study (due to decreased clearance of docetaxel and increased risk of toxicity).
  • Age greater than or equal to 18 years.
  • Fully recovered from acute toxicities from chemotherapy, radiation, or surgery.
  • Negative serum pregnancy test, if patient is female, still fertile, and sexually active.

Exclusion criteria

  • Prior treatment with Doxil or weekly docetaxel. Prior docetaxel administered every 3 weeks is allowed.
  • Evidence of moderate peripheral neuropathy greater than or equal to grade 2.
  • Medical, social, or psychological factors interfering with compliance.
  • Known history of cardiac disease (congestive heart failure, coronary artery disease) that would preclude treatment with Doxil in the opinion of the investigator.
  • Cardiac ejection fraction < 50%
  • Pregnancy

Treatment and study plan

liposomal doxorubicin and docetaxel

Drug

Primary outcomes

  1. To determine the maximum tolerated dose (MTD) of liposomal doxorubicin (Doxil) administered every 4 weeks or every 2 weeks in combination with docetaxel (Taxotere) administered on a weekly schedule

  2. To establish the toxicity profile of this combination

Sponsors and collaborators

Lead sponsor

University of Southern California

Other

Collaborators

  • Tibotec Therapeutics, a Division of Ortho Biotech Products, L.P., USA

Registry information

Official study title

Phase I Trial of Liposomal Doxorubicin (Doxil) and Weekly Docetaxel (Taxotere)

Important dates

Study start
2000
Primary completion
2005
Study completion
2006
First posted
Sep 16, 2005
Registry last updated
May 22, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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