Trial Comparing Simple Follow-up to Exploratory Laparotomy Plus "in Principle" (Hyperthermic Intraperitoneal Chemotherapy) HIPEC in Colorectal Patients

Inclusion criteria

A) Patients presenting with the following history:

• Histologically-proven colorectal adenocarcinoma
• Presenting at the time of resection of the primary with one of the following 4 criteria (criteria indicating a high risk of developing PC) :

• Minimal PC, resected at the same time as the primary
• Ovarian metastases
• Rupture of the primary tumour inside the peritoneal cavity,
• Iatrogenic rupture of the primary tumour during surgery

B) Who have received standard systemic adjuvant chemotherapy (6 months of systemic chemotherapy) :

• Chemotherapy with the Folfox 4 regimen (the current standard treatment ; it can be modified in the future in the two groups, if the standard is modified…).
• Given on an intent-to-treat basis (it can be stopped prematurely for miscellaneous reasons…);

C) Patients who do not present any sign of tumour recurrence at the end of these 6 months of chemotherapy.

D) Patients with the following general characteristics:

• Age between 18 and 70 years,
• Performance Status WHO < 2, life expectancy > 12 weeks,
• Haematological parameters : Polynuclear neutrophils ³ 1.5x109/L, platelets ³ 100x109/L,
• Liver function : Total Bilirubin £ 1.5 x ULN, AST (SGOT) et ALT (SGPT) £ 3 x ULN, alkaline phosphatases £ 3 x ULN,
• Renal function : Plasma creatinine £ 1,25 x ULN,
• Operable patients,
• Grade £ 2 peripheral neuropathy (CTC AE v3.0 annex 7)
• Patients entitled to French National Health Insurance coverage.

E)Patients will be informed and a signed consent form will be obtained before initiating any procedure specific to the trial.

Exclusion criteria

• Cancers of non colorectal origin, particularly, appendiceal cancers are excluded
• Patients presenting with a detectable recurrent tumour
• Grade ≥ 3 Peripheral neuropathy
• History of cancer (excepted cutaneous basocellullar cancer or in situ carcinoma of the uterine cervix) with a recurrence during the 5 previous years
• Patients already included in another trial concerning first-line treatment 6) Pregnant women or likely to be pregnant

• Persons under guardianship 8) Follow-up impossible for geographic, social or psychological reasons