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OpenTrials
Completed

NCT Number: NCT01634477

Trends of Morbidity and Mortality Among Thai HIV-infected and HIV-uninfected Patients: a Five-year Prospective Cohort Study

1. To describe the morbidity and clinical characteristics among HIV-infected patients and HIV-uninfected patients. 2. To identify the risk factors for the complication or morbidity among HIV-infected patients and HIV-uninfected patients. 3. To describe the mortality among HIV-infected patients and HIV-uninfected patients. 4. To identify the risk factors for the cause of death among HIV-infected and HIV-uninfected patients.

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Key information

Conditions

HIV Infection Blood-Borne Infections Cardiovascular Diseases Communicable Diseases Genital Diseases HIV Infections Healthy Immune System Diseases Immunologic Deficiency Syndromes Infections Lentivirus Infections Opportunistic Infections RNA Virus Infections Retroviridae Infections Sexually Transmitted Diseases Sexually Transmitted Diseases, Viral Urogenital Diseases Virus Diseases

Age range

30 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The Thai Red Cross AIDS Research Centre

Pathum Wan, Bangkok, 10330, Thailand

About this study

The information obtained from this study would be very important in planning future holistic care of HIV-infected patients in our institutes as well as in national policy. Results from the study could be used to develop proper long-term management guidelines for people living with HIV (PLHIV) in Thailand targeted at preventable conditions such as metabolic diseases and certain cancers.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

HIV-infected patients group

  • HIV positive
  • 30 years of age or older, both male and female
  • Thai nationality
  • Written research informed consent

HIV-uninfected patients group

  • HIV un-infected
  • 30 years of age or older, both male and female
  • Thai nationality
  • Written research informed consent

Exclusion criteria

HIV-infected patients group

  • Systolic BP ≥ 130 or Diastolic BP ≥ 85mm Hg or on the treatment
  • Fasting blood sugar > 126 mg/dl or on the treatment
  • Proteinuria
  • Creatinine > 1.5 mg/dl
  • Recent hospitalization
  • Patient who are having mental disease HIV-uninfected patients group
  • Systolic BP ≥ 130 or Diastolic BP ≥ 85mm Hg or on the treatment
  • Fasting blood sugar > 126 mg/dl or on the treatment
  • Proteinuria
  • Creatinine > 1.5 mg/dl
  • Recent hospitalization
  • Patient who are having mental disease

Treatment and study plan

Primary outcomes

  1. morbidity

    Time frame: 60 months

    development of other diseases

  2. HIV related illness

    Time frame: 60 months

    development of opportunistic infection such as Non-Hodkin's lymphoma, Kaposi's sarcoma

  3. Non HIV-related illness

    Time frame: 60 months

    development of Dyslipidemia, Hypertension, DM, CVD , Cancer, osteopenia, osteoporosis, Renal disease, liver disease

  4. mortality

    Time frame: 60 months

    death

  5. CVD

    Time frame: 60 months

    development of CVD

Sponsors and collaborators

Lead sponsor

Thai Red Cross AIDS Research Centre

Other

Collaborators

  • Bamrasnaradura Infectious Diseases Institute
  • Chulalongkorn University
  • HIV Netherlands Australia Thailand Research Collaboration
  • Queen Savang Vadhana Memorial Hospital, Thailand

Registry information

Acronym: TNT-HIV

Important dates

Study start
2010
Primary completion
2020
Study completion
2021
First posted
Jul 6, 2012
Registry last updated
Nov 25, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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