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OpenTrials
Active, Not Recruiting

NCT Number: NCT06612671

Treatment Outcomes of Retroperitoneal Sarcoma

Investigators tried condult a retrospective study to analysis the prognostic factors and oncological outcome analysis of Retroperitoneal Sarcoma treated in our high volume medical center.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Retroperitoneal Sarcoma

Age range

20 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Taichung Veterans General Hospital

Taichung, Taiwan

About this study

Retroperitoneal Sarcoma (RPS) which is a rare disease which incidence is 1.79/100,000. The treatment is difficult to due to it anatomy position which often invade to multiple organs and cause the complete surgical resection to be very complex and difficult. It was known to sacrifice one side kidney will improve the resection rate. To this days, successful surgical resection was still the gold standard that provide most benefit in overall survival. To reach that goal, pre-operative radiotherapy was applied to RPS which intended to achieve similar effect in rectal cancer for the down staging effect and improved the respectability but with limited benefit. Herein, investigators conducted this study to find the best way to achieve successful surgical resection and prognostic factor analysis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • the patient who have retroperitoneal maliganacy and receive complete tumor excision in our hospital

Exclusion criteria

  • the patient did not receive complete tumor excision in our hospital
  • the pathological report yielded not malignancy tumor

Treatment and study plan

tumor wide excision

Procedure

patients received properative or post-operative radiotherapy

Other names: Radiation

Primary outcomes

  1. Overall survival

    Time frame: The proportion of patients still alive at 1 year, 3 years, and 5 years after treatment.

    After treatment, patients will undergo long-term follow-up to record their survival status.

Secondary outcomes

  1. Progression free survival

    Time frame: The rates of local recurrence, regional recurrence, or distant metastasis at 1 year, 3 years, and 5 years after treatment.

    Progression defined as local, regional, or distant metastasis

Other outcomes

  1. The resectability of preoperative embolization

    Time frame: From the start of preoperative evaluations to the day of surgery, it typically spans 7 days.

    Preoperative embolization for assessing resectability combines radiology, angiography, and transcatheter arterial embolization (TAE). Initially, imaging techniques such as X-rays or CT scans are used to understand the characteristics of the lesions. Then, angiography is employed to observe the tumor's blood supply. Finally, TAE not only evaluates the vascular supply to the tumor but also helps reduce its size through embolization, enhancing resectability. The comprehensive results of these assessments contribute to developing a safe and effective surgical plan.

  2. The value of eGFR in renal function

    Time frame: Period from date before surgery to the date one year after suregry

    eGFR is an important biomarker used to assess kidney function and monitor renal health. It represents the volume of blood filtered by the glomeruli per minute, typically expressed in milliliters per minute (mL/min). A venous blood sample will be collected and analyzed in the laboratory to determine the value.

Sponsors and collaborators

Lead sponsor

Taichung Veterans General Hospital

Other

Registry information

Official study title

Prognostic Factors and Oncological Outcome Analysis of Retroperitoneal Sarcoma

Important dates

Study start
2023
Primary completion
2024
Study completion
2025
First posted
Sep 25, 2024
Registry last updated
Sep 25, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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