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Completed

NCT Number: NCT01101373

Treatment of Severe Depressive Illness by Targeted Brain Surgery

This study will report on the outcome of a clinical program, operational since 1998, that has used surgery targeting an emotional pathway in the brain in the treatment of severe depressive illness that has failed to respond to all other available interventions. Benefit from surgery was anticipated on the basis that the lesion (bilateral anterior capsulotomy) is a well established surgical target for treating severe treatment resistant depression.

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Key information

Conditions

Major Depressive Disorder Depressive Disorder Depressive Disorder, Major Mental Disorders Mood Disorders

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

UBC Hospital, 2255 Wesbrook Mall

Vancouver, British Columbia, V6T 2A1, Canada

About this study

Since 1998 bilateral anterior capsulotomy (BAC) has been available to patients in British Columbia Canada who have treatment refractory severe depressive illness. This study will report on the outcome of patients who have received this intervention. BAC is achieved by stereotactic radiofrequency lesioning. To date 8 patients have received BAC. For all patients there is follow-up data of at least 24 months. The purpose of this retrospective study is to report on the surgical protocol and to demonstrate the efficacy and safety of BAC in severe depression.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Severe treatment resistant depression of at least 5 years duration
  • older than 18 years

Exclusion criteria

  • Comorbid organic mental disorder
  • Delusional disorder
  • Substance disorder
  • Neurological disease
  • Cluster B personality disorder

Sponsors and collaborators

Lead sponsor

University of British Columbia

Other

Registry information

Official study title

Bilateral Anterior Capsulotomy For Intractable Depression

Important dates

Study start
2000
Primary completion
2009
Study completion
2010
First posted
Apr 9, 2010
Registry last updated
Nov 19, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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