Skip to main content
OpenTrials
Completed

NCT Number: NCT00166192

Treatment of Melasma With Jessner's Solution vs. Trichloroacetic Acid

Melasma is an acquired discoloration of the skin characterized by brown patches. Chemical peels using agents such as Jessner's solution and trichloroacetic acid (TCA) are commonly used to treat melasma. A chemical peel involves applying the peeling agent to the skin for a short period. The skin will peel similar to a sunburn, and moisturizers are applied to the skin. Although both agents are well-accepted, there have been no good comparisons of the two agents. The purpose of this study is determine if there is a difference in the effectiveness of these two agents.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Melasma Hyperpigmentation Melanosis Pigmentation Disorders Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Emory University Dermatology Clinic

Atlanta, Georgia, 30322, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults > 18 years old
  • Clinical diagnosis of melasma
  • Mental capacity to give informed consent

Exclusion criteria

  • Pregnancy
  • H/o allergy to Jessner's solution, tricholoracetetic acid, tretinoin, or hydroquinone
  • Active dermatitis
  • Presence of cutaneous infection

Treatment and study plan

Jessner's solution chemical peel

Procedure

Trichloroacetic acid chemical peel

Procedure

Primary outcomes

  1. Clinical efficacy by clinician's evaluation

    Time frame: 3 months

    Hyperpigmenation Global Score

Secondary outcomes

  1. Efficacy by subject's evaluation

    Time frame: 3 months

    Hyperpigmentation Global Score

Sponsors and collaborators

Lead sponsor

Emory University

Other

Registry information

Official study title

Treatment of Melasma With Jessner's Solution vs. Trichloroacetic Acid: A Comparison of Clinical Efficacy

Important dates

Study start
2008
Primary completion
2010
Study completion
2013
First posted
Sep 14, 2005
Registry last updated
Nov 14, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.