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Completed

NCT Number: NCT04410679

Treatment of Internal Inflammatory Root Resorption Using Injectable PRF Revascularization Technque

Currently Endodontics looks forward for regeneration rather than repair. Regenerative endodontic therapy was limited to pulp revascularization of necrotic pulp in immature teeth , followed by mature teeth. Recently pulp revascularization technique by induction of blood clot was applied in the treatment of inflammatory root resorption. So far, no clinical study for management of teeth with inflammatory internal root resorption by using injectable PRF revascularization has been described in the literature. Thus, this is the first clinical attempt to manage inflammatory root resorption in necrotic incisor teeth using injectable PRF regenerative approach.

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Key information

Conditions

Root Resorption Stomatognathic Diseases Tooth Diseases Tooth Resorption

Age range

13 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of dentistry Fayoum University

Al Fayyum, Egypt

About this study

13 teeth in a total of 10 patients with inflammatory root resorption will be treated using revascualrization technique, iPRF will be prepared and unjected in the canal after previous canal disinfection with calcium hydroxide for 2-4 weeks. cBCT will be taken preoperative and 12 month follow up period, also clinical and radiographic follow uo will be considered every 3 months for 1 year.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients 13-30 years old
  • no sex predilection
  • medically free
  • Suffering from internal inflammatory root resorption in permanent anterior mature teeth
  • associated with or without periapical radiolucency
  • no or grade I tooth mobility, and a pocket depth <3 mm

Exclusion criteria

  • old age
  • Medically medically compromised patients

Treatment and study plan

Injectable PRF

Biological

blood sample and centrifuged to obtain i-PRF

Primary outcomes

  1. change in volumetric size of internal root resorption lesions

    Time frame: 12 months

    Measuring volumetric dimensions of resorption lesion pre and postoperatively using CBCT

Secondary outcomes

  1. change in volumetric size of periapical lesions

    Time frame: 12 months

    Measuring volumetric dimensions of periapical lesion pre and postoperatively using CBCT

Sponsors and collaborators

Lead sponsor

Fayoum University

Other

Registry information

Official study title

Treatment of Internal Inflammatory Root Resorption Using Injectable PRF Revascularization Technique: A Clinical Study With Cone Beam Computed Tomography Evaluation

Important dates

Study start
2018
Primary completion
2019
Study completion
2020
First posted
Jun 1, 2020
Registry last updated
Oct 8, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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