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OpenTrials
Completed

NCT Number: NCT01238393

Treatment of Epiretinal Membranes With Ranibizumab

The purpose of this study is to determine whether intraocular injection of ranibizumab decreases the retinal thickness in patients with epiretinal membranes and reduces associated symptoms.

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Key information

Conditions

Epiretinal Membrane Eye Diseases Retinal Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Queen's University, Hotel Dieu Hospital

Kingston, Ontario, K7L 5G2, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • symptomatic idiopathic epiretinal membrane

Exclusion criteria

  • vision worse than 6/18 and fit for surgery
  • prior vitreoretinal surgery or injection
  • diabetes
  • any past or current form of retinal vein occlusion or neovascularization
  • age-related macular degeneration
  • other condition causing significant limitation of visual potential

Treatment and study plan

Intravitreal ranibizumab

Drug

monthly injections x3 +/- 2nd series of 3

Other names: Lucentis

Primary outcomes

  1. Evidence of improvement measured by optical coherence tomography

    Time frame: 3 and 6 months

Secondary outcomes

  1. Distance visual acuity (ETDRS)

    Time frame: 3 and 6 months

  2. Near visual acuity (Snellen)

    Time frame: 3 and 6 months

  3. Subjective change in symptoms

    Time frame: 3 and 6 months

  4. Amsler grid improvement

    Time frame: 3 and 6 months

  5. Quality of life improvement

    Time frame: 6 months

Sponsors and collaborators

Lead sponsor

Queen's University

Other

Registry information

Official study title

A Prospective Pilot Study of Lucentis for Epiretinal Membranes: the LERM Study

Acronym: LERM

Important dates

Study start
2010
Primary completion
2011
Study completion
2012
First posted
Nov 10, 2010
Registry last updated
Jan 13, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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