Treatment of Abdominal Abscesses With or Without Fibrinolysis

The objective of this study is to evaluate the utility of fibrinolysis when draining an abdominal abscess as defined by length of stay after drainage.

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Key information

Conditions

Abdominal Abscess Abscess Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Suppuration Tissue Plasminogen Activator

Age range

Up to 17 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Children's Mercy Hospital

Kansas City, Missouri, 64108, United States

About this study

The hypothesis is that fibrinolysis of a abscess will shorten hospital stay compared to drainage alone.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients under age 18 found to have an abscess in their abdomen related to perforated appendicitis that requires a drain either prior to or after appendectomy.

Exclusion criteria

Patients with known immune deficiency per medical record review
Patients with another condition affecting surgical decision making or recovery
Patients with drain unable to be placed

Treatment and study plan

Tissue plasminogen activator abscess flush

Procedure

Thirteen ml of 10% tPA in saline at time of drain and twice daily thereafter.

Other names: fibrinolytic abscess flush

Saline flush of abscess

Procedure

Thirteen ml of saline is used to flush abscess at time of drain placement and twice daily thereafter.

Other names: Standard saline flush of abscess

Primary outcomes

Length of hospital stay

Time frame: 1-2 weeks

Length of time required for meeting discharge criteria

Sponsors and collaborators

Lead sponsor

Children's Mercy Hospital Kansas City

Other

Registry information

Important dates

Study start: 2009
Primary completion: 2014
Study completion: 2014
First posted: May 14, 2012
Registry last updated: Feb 4, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed