Treatment Duration on Normobaric Hyperoxia in Acute Ischemic Stroke

Inclusion criteria

• Symptoms and signs were consistent with acute anterior circulation stroke,
• NIHSS score≥6分;Alberta Stroke Program Early CT score (ASPECTS)≥6;
• Met the indications for endovascular therapy;
• (Level of consciousness)NIHSS score 0 or 1; MRS score was 0-1 before stroke
• The time from onset to randomization was within 24 hours;
• Preoperative CTA or MRA confirmed the presence of large vessel occlusion (internal carotid artery or middle cerebral artery M1, M2 segments);
• Patients and their families signed informed consent

Exclusion criteria

• Rapid neurological function improvement, NIHSS score less than 10 points, or evidence of vessel recanalization prior to randomization;
• Seizures at stroke onset;
• Intracranial hemorrhage;
• Symptoms suggestive of subarachnoid hemorrhage, even if CT scan was normal;
• Known hemorrhagic diathesis, coagulation factor deficiency, or on anticoagulant therapy with INR > 3.0 or PTT > 3 times normal;
• Platelet count of less than 100,000 per cubic millimeter;
• Severe hepatic or renal dysfunction;
• Severe, sustained hypertension (Systolic Blood Pressure >185 mmHg or Diastolic Blood Pressure >110 mmHg)
• Baseline blood glucose of <50mg/dL (2.78 mmol) or >400mg/dL (22.20 mmol) Active and chronic obstructive pulmonary disease or acute respiratory distress syndrome;
• >3 L/min oxygen required to maintain peripheral arterial oxygen saturation (SaO2) 95% as per current stroke management guidelines;
• Medically unstable;
• Life expectancy<90 days;
• Patients who could not complete the 90-day follow-up;
• Evidence of intracranial tumor;
• Patients with anemia or polycythemia vera or other situations that require urgent oxygen inhalation;
• Patients with upper gastrointestinal bleeding or nausea or vomiting so that they cannot cooperate with the mask to inhale oxygen.
• A history of severe allergies to contrast agents;