Skip to main content
OpenTrials
Completed

NCT Number: NCT00018824

Treating Alcohol Use In Older Adults With Depression

The purpose of this study is to test the efficacy combining a treatment for depression with a treatment for alcohol dependence.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Alcoholism Alcohol-Related Disorders Behavior Behavioral Symptoms Chemically-Induced Disorders Depression Mental Disorders Substance-Related Disorders

Age range

55 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

About this study

This study aims to study 80 patients with comorbid alcohol dependence and a depressive syndrome. After appropriate detoxification, patients are started on either naltrexone 50 mg or placebo. After one week, sertraline is added in an open label fashion. It is hypothesized that those patients receiving combination therapy will last 3 months with follow-up tracking lasting 1 year.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age > 55
  • Current depressive syndrome
  • Current alcohol dependence
  • No psychosis
  • No opioid or cocaine abuse or dependence

Exclusion criteria

Treatment and study plan

Naltrexone

Drug

Placebo

Drug

Primary outcomes

  1. Alcohol use'

    Time frame: 12 weeks

Sponsors and collaborators

Lead sponsor

US Department of Veterans Affairs

Fed

Registry information

Official study title

The Treatment of Late Life Major Depression Complication by Alcohol

Important dates

Study start
1999
Primary completion
2005
Study completion
2005
First posted
Jul 5, 2001
Registry last updated
Sep 23, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.