Treatable Traits of Severe Asthma

Inclusion criteria

• Must be at least 18 years old and have resided in Beijing for at least 6 months.
• Must meet the diagnostic criteria for asthma as outlined in the 2023 GINA guidelines, have written evidence of variable airflow limitation, and have been receiving asthma treatment for at least 6 months.
• Must meet one or both of the following criteria as defined in the 2023 GINA guidelines for uncontrolled asthma: poor symptom control (defined as an Asthma Control Questionnaire (ACQ-5) score of 0.75 or higher); frequent acute exacerbations (≥2 per year) requiring oral corticosteroids, or severe acute exacerbations (≥1 per year) requiring emergency or hospitalization.
• Willing to undergo a multidisciplinary, multi-dimensional evaluation and sign an informed consent form.
• Must meet the criteria for severe asthma as outlined in the 2023 GINA guidelines

Exclusion criteria

• Use macrolides within 4 weeks of the screening period
• Use anti-IgE, anti-IL-5, or anti-IL-5R therapy within 4 weeks of the screening period
• Use inhaled ICS + LABA + long-acting muscarinic antagonist (LAMA) within 4 weeks of the screening period
• Be allergic to macrolides
• Have a QTc interval prolongation of >480ms
• Take a medication that interacts with azithromycin to prolong the QTc interval or cause existing ECG abnormalities, which may lead to arrhythmias.