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OpenTrials
Completed

NCT Number: NCT00753051

Treat Clozapine ( CLZ )-Resistant Schizophrenia Comparing CLZ + Haloperidol vs. CLZ + Electroconvulsive Therapy (ECT)

Clozapine treatment resistant schizophrenia is still prevalent.The effectiveness of augmenting clozapine : one augmenting with haloperidol and the other with electroconvulsive therapy should be determined.This study is a randomized control trial.

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Key information

Conditions

Schizophrenia Mental Disorders Schizophrenia Spectrum and Other Psychotic Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Psychiatry.Faculty of Medicine.KhonKaen University.

Muang, KhonKaen, 40002, Thailand

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • schizophrenic patients diagnosed with schedules for clinical assessment in neuropsychiatry ( SCAN )in accordance with DSM-IV-TR or ICD-10
  • Resistant to at least 6 weeks of clozapine treatment in therapeutic dosage
  • Voluntary to participate the research protocol expressed by signing informed consent form

Exclusion criteria

  • Patient does not volunteer himself or herself
  • Patient is having epilepsy, DM, cardiac disease, autistic disorder and illiterate
  • Patient is deaf, blind , dumb to obstruct good communication

Treatment and study plan

clozapine+haloperidol

Drug

clozapine 300-900 mg/d haloperidol 4-60 mg/d

Other names: clopaze, haloperidol

clozapine,electroconvulsive therapy

Drug

clozapine 300-900 mg/d electroconvulsive therapy 4-12 times

Other names: clopaze , Thymatron ECT machine

Primary outcomes

  1. PANSS , HAM-D , CGI , AIMS Scores

    Time frame: every 4 weeks for 24 weeks

Sponsors and collaborators

Lead sponsor

Khon Kaen University

Other

Registry information

Official study title

Treatment of Clozapine-resistant Schizophrenia : Comparison Between Augmentation With Haloperidol and Electroconvulsive Therapy

Acronym: TCRS

Important dates

Study start
2008
Primary completion
2012
Study completion
2012
First posted
Sep 16, 2008
Registry last updated
May 7, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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