Transpulmonary Pressure in Right Ventricle Protection of ARDS

To compare the effect between mechanical ventilation strategy guided by transpulmonary pressure and tranditional lung protective ventilation strategy in acute respiratory distress syndrome for right ventricle protection.

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Key information

Conditions

Acute Respiratory Distress Syndrome Acute Cor Pulmonale Lung Diseases Respiration Disorders Respiratory Distress Syndrome Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Beijing Chao-Yang Hospital

Beijing, Beijing Municipality, 100020, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

duration of invasive mechanical ventilation less than 72 hours;
meet the diagnostic criteria of Berlin definition for ARDS;
age older than 18

Exclusion criteria

esophageal surgery or damage;
cardiac surgery;
severe bronchopleural fistula;
serious arrhythmia; pneumothorax;
tricuspid stenosis;
heparin allergy;
chronic pulmonary heart disease

Treatment and study plan

mechanical ventilation strategy guided by transpulmonary pressure

Procedure

Mechanical ventilation parameters adjust guided by transpulmonary pressure monitoring. For pressure assist control or volumn assit control mode; inspiratory pressure or volumn setting needs to maintain Ppeak less than 25 cm H2O; PEEP was set at such a level that expiratory Ptp stayed between 0 and 5 cm H2O.

Primary outcomes

Pulmonary vascular resistance (PVR)

Time frame: 3 days

PVR will measured by Swan-Ganz catheter
Pulmonary vascular compliance

Time frame: 3 days

Pulmonary vascular compliance will be calculated using pulmonary artery pressure divided by stroke output measured by Swan-Ganz catheter.

Sponsors and collaborators

Lead sponsor

Beijing Chao Yang Hospital

Other

Registry information

Official study title

Transpulmonary Pressure Guided Mechanical Ventilation Strategy for Right Ventricle Protection in Acute Respiratory Distress Syndrome

Important dates

Study start: 2023
Primary completion: 2024
Study completion: 2024
First posted: Nov 29, 2022
Registry last updated: Mar 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed