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Completed

NCT Number: NCT02866513

Transpulmonary Pressure and Airway Pressure Release Ventilation (APRV).

Mechanical ventilation can induce pulmonary lesions called ventilator induced lung injury (VILI). High levels of Transpulmonary pressure is one of the most important mechanism of VILI during the use of mechanical ventilation. The use of bilevel pressure ventilator modes like APRV could generate high levels of transpulmonary pressure.

The aim of this study is to evaluate the variations of transpulmonary pressure during the use of APRV by clinicians

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Key information

Conditions

Patient Mechanically Ventilated With APRV Mode

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Assistance Publique Hôpitaux de Marseille hôpital de la Timone

Marseille, 13354, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult
  • Patient mechanically ventilated for more than 48 H for acute respiratory failure
  • Decision to use of the APRV mode by clinicians in charge of the patient

Exclusion criteria

  • Contraindication for the use of a nasogastric tube

Treatment and study plan

evaluate the variations of transpulmonary pressure during the use of APRV by clinicians.

Other

Primary outcomes

  1. Transpulmonary pressure

    Time frame: 24 hours

    Measurement of transpulmonary pressure needs the measurement of oesophageal pressure with a specific nasogastric tube. This measurement is now available in routine in few mechanical ventilators in intensive care units (eg: AVEA Ventilator. Vyasys HealthCare). Transpulmonary pressure is the difference between airway pressure and oesophageal pressure and it is now easy to obtain and monitor at the bedside with these ventilators. It is also possible to record the value furthermore than 24 hours.

Secondary outcomes

  1. Maximal value of transpulmonary pressure

    Time frame: 24 hours

    Value of tidal volume > 8 ml/kg

Sponsors and collaborators

Lead sponsor

Assistance Publique Hopitaux De Marseille

Other

Registry information

Official study title

Incidence of High Levels of Transpulmonary Pressure During the Use of Airway Pressure Release Ventilation.

Important dates

Study start
2016
Primary completion
2016
Study completion
2017
First posted
Aug 15, 2016
Registry last updated
Nov 14, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.