TRANSPARK_LONG: The Diagnostic Value of Early Transcranial Ultrasound in Patients With Extrapyramidal Diseases in a Swedish Population

Popular science summary of the project The purpose of the study is to investigate in a Swedish population how well the investigators' previous ultrasound findings match the final diagnosis (PD, APS or ET) after a particularly long follow-up time, which greatly increases the certainty that the diagnosis does not change more and is thus correct. Furthermore, the investigators want to study whether the initial ultrasound findings have changed during the control interval and whether measurement results regarding the diameter in one of the fluid-filled rooms in the brain (third ventricle) can be correlated with the development of cognitive impairment or dementia later in the course of the disease. For this, this study have got ethical permission to go into the patients' medical records and to call a subgroup back to the clinic to be able to do a new examination and a memory test.

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Key information

Conditions

Parkinsonism Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Dementia Dyskinesias Mental Disorders Movement Disorders Nervous System Diseases Neurocognitive Disorders Neurologic Manifestations Parkinsonian Disorders Pathological Conditions, Signs and Symptoms Signs and Symptoms Tremor

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Skåne Univ Hospital

Malmö, Skåne County, 20502, Sweden

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with parkinsonism or essential tremor who came into contact with our clinic before 2017
Satisfactory transcranial bone window
Previous TU (clinical indication)

Exclusion criteria

No transcranial bone window

Treatment and study plan

Primary outcomes

Correlation

Time frame: over 7-10 yrs

Is hyperechogenicity of substantia nigra at mesencephal plane (measured bilaterally in mm2 by transcranial b-mode sonography correlated with a high percentage of patients with classical Parkinsons Disease in contrast to atypical parkinsonism patients?

Secondary outcomes

Correlation

Time frame: 7-10 (retrospective)

Is 3rd ventricle atrophy (measured in mm by b-mode transcranial sonography) correlated with a high % of demented patients in the cohort?

Sponsors and collaborators

Lead sponsor

Region Skane

Other

Registry information

Official study title

TRANSPARK_LONG: The Diagnostic Value of Early Transcranial Ultrasound in Patients With Extrapyramidal Diseases in a Swedish Population: an Evaluation in the Form of a Retrospective Cohort Study With a Long Follow-up Time

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2025
First posted: Sep 13, 2023
Registry last updated: Jul 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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