Transoesophageal Echocardiography in Liver Transplantation

Severe hypotension during reperfusion in liver transplantation is a frequent adverse event. Rare data exist so far about pathophysiology of this phenomenon. The exact role of left ventricular function, which might be impaired causing hypotension, has not been elucidated during the period of reperfusion.

Goal of this study is to:

* perform transesophageal echocardiography in order to assess systolic and diastolic left ventricular function during reperfusion * determine inflammatory mediators in the plasma which could cause left ventricular dysfunction

Completed

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Key information

Conditions

End Stage Liver Disease Digestive System Diseases Hepatic Insufficiency Liver Diseases Liver Failure

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital Zurich, Institute for Anesthesiology

Zurich, Switzerland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients on waiting list for liver transplantation.
Age: 18-75 years.

Exclusion criteria

Strictures, tumours and diverticula of the oesophagus.
History of oesophageal varices with recent bleeding.
Oesophageal varices and prothrombin time less than 20% or platetlets les than 30000/ml.
Instable cervical spine.
Involvement in other studies.

Treatment and study plan

Transoesophageal echocardiography

Behavioral

Transoesophageal echocardiography in liver transplantation: left ventricular function during reperfusion

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Registry information

Official study title

Transoesophageal Echocardiography in Liver Transplantation: Left Ventricular Function During Reperfusion

Important dates

Study start: 2006
Primary completion: 2010
Study completion: 2010
First posted: Oct 23, 2007
Registry last updated: Apr 10, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed