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NCT Number: NCT06333301

Translational Initiative to Map Epigenetics in Sleep

The primary aim of TIME-ZZZ is to explore the relationship between chronotype, incidence of depression and biological age, and whether individuals working "out-of-phase" with their chronotype are more likely to exhibit signs of depression and accelerated biological aging.

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Key information

Conditions

Biological Aging

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

About this study

Understanding the relationship between chronotype, depression, and biological age is important in the field of sleep research and mental health. Sleep patterns and their alignment with an individual's internal body clock, or chronotype, have been increasingly recognized as influential factors in various aspects of well-being, including mental health and overall physiological aging. By conducting a study that investigates the potential correlation between chronotype, incidence of depression, and biological age, along with the impact of working "out-of-phase" with one's chronotype, the investigators can shed light on crucial aspects of sleep, mental health, and their interplay with biological aging.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Has taken an INDEX test within the last 3 months
  • Has registered at least 1 INDEX kit via the Elysium Health website
  • Able and willing to provide digital consent to the RSCF, and the TIME-ZZZ Research Subject Consent Form

Exclusion criteria

  • Consent to participate not given

Treatment and study plan

Surveys

Other

Group will complete several surveys

Primary outcomes

  1. Effect of being "out of phase" with chronotype on biological age

    Time frame: At baseline

    Determine whether individuals working "out-of-phase" with their chronotype (from TIME-ZZZ survey responses) exhibit higher rates of biological aging compared to those working within their chronotype

Secondary outcomes

  1. Effect of Chronotype Alignment and Depression Risk in Relation to Rate of Aging

    Time frame: At baseline

    Determine the effect of chronotype alignment and depression risk (from TIME-ZZZ surveys) on biological rate of aging

  2. Identification of DNA methylation markers associated with chronotype

    Time frame: At baseline

    Identify specific DNA methylation markers associated with chronotype (from TIME-ZZZ surveys) thereby providing potential insights into the epigenetic regulation of sleep-wake patterns

  3. Identification of DNA methylation markers associated with depression

    Time frame: At baseline

    Identify specific DNA methylation markers associated with depression (from TIME-ZZZ surveys) potentially shedding light on the underlying epigenetic mechanisms involved in the development and progression of depressive disorders.

Study contacts

Contact information is provided by the study sponsor or research team.

Ryan W Dellinger, PhD

CONTACT

[email protected]

8882206436

Sponsors and collaborators

Lead sponsor

Elysium Health

Industry

Collaborators

  • University of Oxford

Registry information

Acronym: TIME-ZZZ

Important dates

Study start
2024
Primary completion
2034
Study completion
2034
First posted
Mar 27, 2024
Registry last updated
Mar 27, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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