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NCT Number: NCT04864080

Transdiagnostic Cognitive Biomarkers

The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cognitive dysfunction. Completing behavioral paradigms with electrophysiology and TMS is a challenging frontier. This study focuses on the feasibility of such an endeavor for those with chronic pain or depression as well as healthy controls.

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Key information

Conditions

Pain Behavior Behavioral Symptoms Depression Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Minnesota

Minneapolis, Minnesota, 55455, United States

Location status: Recruiting

Location contact

David Darrow

CONTACT

[email protected]

612-946-1424

About this study

This study aims to test the feasibility of procedures aimed at discovering transdiagnostic biomarkers for cognitive impairment in chronic pain and depression. Fifteen healthy control participants and 15 participants from each disease group (chronic pain, depression) will be recruited.

Using a task-based fmri, TMS will be targeted for priming of the Left DLPFC. EEG will be used during our behavioral paradigm to compare changes in DLPFC function before and after primed TMS.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Arm 1, healthy controls:

Inclusion criteria

  • Have access to the online study platform.

Exclusion criteria

  • under 18, non-English speaking

Arm 2: pain and depression:

Inclusion criteria

  • Pain or depression

Exclusion criteria

  • pregnant women

Treatment and study plan

Computer game/task

Behavioral

N-back, COGED, PacMan game, Bandit task, Websurf task.

Other names: Behavioral tasks online and in-person.

Health surveys online

Behavioral

Health surveys to study themes like pain, sleep, depression and anxiety, and PTSD.

Other names: PHQ-9, MASQ, GAD-7

Primary outcomes

  1. Feasibility for all aspects of the study

    Time frame: 1-7 days

    Feasibility; the overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cognitive dysfunction. Completing behavioral paradigms with electrophysiology and TMS is a challenging frontier. This study focuses on the feasibility of such an endeavor for those with chronic pain or depression as well as healthy controls.

Secondary outcomes

  1. Acceptability

    Time frame: 1-7 days

    Sum total of acceptability rating scale of study procedures.

Study contacts

Contact information is provided by the study sponsor or research team.

David Darrow

CONTACT

[email protected]

(612) 624-6666

MATTHEW D Maple

CONTACT

[email protected]

612-946-1424

Sponsors and collaborators

Lead sponsor

University of Minnesota

Other

Registry information

Important dates

Study start
2022
Primary completion
2027
Study completion
2027
First posted
Apr 28, 2021
Registry last updated
Mar 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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