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Completed

NCT Number: NCT02583633

Transdermal Nitroglycerin and Nifedipine in Preterm Labor

One of the important complications of pregnancy is preterm labor (PTL) and delivery. There are different tocolytic agents to enhance the time of delivery. The aim of this study was to compare the effect of transdermal nitroglycerin (glyceryl trinitrate, GTN) and oral nifedipine for managing preterm labor. This was a randomized clinical trial in women admitted with diagnosis of PTL. Group one have received transdermal GTN whereas group two have received oral nifedipine, vital signs, FHR, contractions, dilation and effacement as well as gestation age at the time of delivery have been monitored and evaluated in both groups of patient. Our main goal has been delay of delivery to have the most beneficial effect of primary corticosteroid administration for fetus.

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Key information

Conditions

Managing Preterm Labor

Age range

18 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • GA between 24 to 34 weeks
  • early-onset signs of delivery (≥4 uterine contractions during 20 minutes, ≥1 centimeters (cm) of dilation and effacement over 80%).

Exclusion criteria

  • maternal or fetal life-threatening conditions which require emergency termination
  • multiple pregnancy
  • premature rupture of membrane
  • fatal anomaly or intra-uterine fetal death
  • cervical dilation ≥4 cm
  • any tocolytic treatment in previous days and positive allergy to GTN

Treatment and study plan

transdermal nitroglycerin

Drug

nifedipine

Drug

Primary outcomes

  1. Time of Delivery

    Time frame: Delivery

Secondary outcomes

  1. APGAR scores

    Time frame: Delivery

    The Apgar scale is determined by evaluating the newborn baby on five simple criteria on a scale from zero to two, then summing up the five values thus obtained. The resulting Apgar score ranges from zero to 10. The five criteria are summarized using words chosen to form a backronym (Appearance, Pulse, Grimace, Activity, Respiration).

    The Apgar scale is determined by evaluating the newborn baby on five simple criteria on a scale from zero to two, then summing up the five values thus obtained. The resulting Apgar score ranges from zero to 10. The five criteria are summarized using words chosen to form a backronym (Appearance, Pulse, Grimace, Activity, Respiration).

Sponsors and collaborators

Lead sponsor

Shiraz University of Medical Sciences

Other

Registry information

Official study title

Transdermal Nitroglycerin and Nifedipine for Managing Preterm Labor: a Randomized Clinical Trial

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Oct 22, 2015
Registry last updated
Oct 22, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.