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Completed

NCT Number: NCT02013596

Transcutaneous Electrical Acupoint Stimulation(TEAS) for Hepatic and Renal Dysfunction After Pneumoperitoneum

The purpose of this study is to compare the effect of TEAS pretreatment and treatment on hepatic and renal dysfunction induced by pneumoperitoneum in patients undergoing laparoscopic surgeries.

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Key information

Conditions

Hepatic Dysfunction Transient Digestive System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Liver Diseases Male Urogenital Diseases Peritoneal Diseases Pneumoperitoneum Renal Function Disorder Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Xijing Hospital, Fourth Military Medical University

Xi'an, Shaanxi, 710032, China

About this study

Patients were randomly assigned to three groups, control group and two intervention groups, receiving TEAS before and after general anesthesia induction respectively. TEAS was given through electrodes attached to acupoints. The time for TEAS was 30min. Venous blood samples were collected before and 20min after pneumoperitoneum. Hepatic and renal function index including AST, ALT, ALP, BUN, Cr were measured.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age>18yrs,<60yrs；
  • ASA 1-2；
  • Scheduled for laparoscopic surgery under general anesthesia；
  • Informed consented

Exclusion criteria

  • Patients with hepatic or renal dysfunction；
  • Patients with severe hypertension or cardiac dysfunction；
  • Patients with severe pulmonary disease；
  • Patients with hemoglobin<100g/L

Treatment and study plan

TEAS pretreatment

Other

Electric stimulation was given through electrode attached to specific acupoints for 30mins before anesthesia induction

TEAS treatment

Other

Transcutaneous Electrical Acupoint Stimulation was given to the patient at the same time of the start of anesthesia induction for 30mins

Primary outcomes

  1. Incidence of renal or hepatic dysfunction

    Time frame: 20min after pneumoperitoneum

    percentage of patients with renal or hepatic dysfunction

Secondary outcomes

  1. Change of hepatic function

    Time frame: 20min after pneumoperitoneum

    the increase of hepatic ALT and AST after pneumoperitoneum

  2. Change of renal function

    Time frame: 20min after pneumoperitoneum

    Change of BUN and Cr after pneumoperitoneum

Sponsors and collaborators

Lead sponsor

Zhihong LU

Other

Registry information

Official study title

Effect of Transcutaneous Electrical Acupoint Stimulation(TEAS) on the Hepatic and Renal Function Impaired by Pneumoperitoneum: a Prospective, Randomized Controlled Trial

Acronym: TRIP

Important dates

Study start
2013
Primary completion
2015
Study completion
2015
First posted
Dec 17, 2013
Registry last updated
Jan 14, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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