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OpenTrials
Completed

NCT Number: NCT05060770

Transcriptomic Study of IBD-associated Colorectal Cancer

Chronic inflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer (CRC) in historical cohorts. The pathways of oncogenesis of these CRCs, which are very different clinically from de novo CRCs, are currently unknown. The aim of our work is to identify specific molecular signatures of CRC occurring in the setting of IBD.

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Key information

Conditions

Colorectal Cancer, Genetics of Colonic Diseases Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastroenteritis Gastrointestinal Diseases Gastrointestinal Neoplasms Inflammatory Bowel Diseases Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Rectal Diseases

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Person 18 years of age or older
  • Person with colorectal cancer in the context of IBD
  • Person who has received complete information on the organization of the research and who has signed an informed consent
  • Person affiliated to a social security plan or beneficiary of such a plan.

Exclusion criteria

  • Person referred to in articles L. 1121-5, L. 1121-7 and L1121-8 of the public health code:
  • Pregnant woman, parturient or nursing mother
  • Minor (not emancipated)
  • Adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice)
  • Person of legal age who is unable to express his or her consent
  • Person deprived of liberty by a judicial or administrative decision, persons subject to psychiatric care under articles L. 3212-1 and L. 3213-1.

Treatment and study plan

transcriptomic analysis

Genetic

transcriptomic analysis on preserved tumor tissue

Primary outcomes

  1. IBD associated CRC oncogenesis

    Time frame: 1 year

    Percentage of gene expression variation in CRC tumor tissue samples in the following groups patients with CRC and IBD

Sponsors and collaborators

Lead sponsor

Central Hospital, Nancy, France

Other

Registry information

Official study title

Transcriptiomic Analysis of Inflammatory Bowel Disease-associated Colorectal Cancer. A French Retrospective Study of 26 Cases Identified at the Nancy University Hospital

Important dates

Study start
2010
Primary completion
2021
Study completion
2021
First posted
Sep 29, 2021
Registry last updated
Oct 7, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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