Transcriptomic Analysis of Incisional Hernia Based on High-throughput Sequencing Technology

This study included patients who underwent surgical treatment for incisional hernia and non-hernia conditions. Surgical specimens were collected for transcriptome sequencing to obtain the gene expression list. Then genes analyzed by Gene Ontology, protein interactions, and signaling pathway enrichment using the expression matrix.

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Key information

Conditions

Incisional Hernia Extracellular Matrix Alteration Hernia Pathologic Processes Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Postoperative Complications

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hua Dong Hospital Affiliated to Fu Dan University

Shanghai, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

1.18 to 75 years 2.diagnosed with incisional hernia 3.normal tumour markers 4.elective surgery patients.

Exclusion criteria

patients with vital organ failure (heart liver, lung, kidney and others)
malignant tumors not been completely relieved by active treatment,
patients who have psychiatric diseases or comprehension disorders.
patients with metabolic disease involving connective tissue collagen.

Treatment and study plan

Transcriptomic analysis

Diagnostic Test

high-throughput sequencing technology

Primary outcomes

the gene expression list

Time frame: 2023.3-2023.9

the gene expression list

Sponsors and collaborators

Lead sponsor

Fudan University

Other

Registry information

Important dates

Study start: 2023
Primary completion: 2023
Study completion: 2024
First posted: Apr 16, 2024
Registry last updated: Apr 16, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed