NCT Number: NCT03925311
The aim of this study is to correlate and identify the biochemical markers which may reflect WOI. Blood samples will be collected and endometrial biopsy will be performed at particular time points.
Interested in participating?
Request Info20 year–40 year
Female
Observational
Hong Kong
Location status: Recruiting
Chi Chiu Wang, MBBS, PhD
SUB_INVESTIGATOR
Hiu Tan Margaret Lee
CONTACT
Jin Huang, MBBS, PhD
SUB_INVESTIGATOR
Pui Wah Jacqueline Chung, MBBS
CONTACT
Tin Chiu Li, MBBS, PhD
SUB_INVESTIGATOR
Xiaoyan Chen, MBBS, MPhil, PhD
SUB_INVESTIGATOR
Endometrial receptivity in the midluteal phase of the menstrual cycle, known as the window of implantation (WOI), occurs only for a very short period of time. However, so far, there is no reliable clinical and biochemical indicators of WOI. Therefore, this study is to correlate and identify the biochemical markers which may reflect WOI.
participants will be asked to be:
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Age 20-40 years.
Exclusion criteria
patient will be performed endometrial biopsy and collected blood samples at particular time points
Time frame: From the day of endometrial biopsy through study completion, an average of 2 months
RNA per sample will be prepared into two portions. One is for RNA sequencing and the other is for small RNA sequencing. The next step is hydrolysis of RNA into 200-300 nucleotides prior to reverse transcription. When sequencing RNA other than mRNA the library preparation is modified. The cellular RNA is selected based on the desired size range. For miRNA, the RNA is isolated through size selection. Once isolated, linkers are added to the 3' and 5' end then purified. The final step is cDNA generation through reverse transcription.
Time frame: From the day of endometrial biopsy through study completion, an average of 2 months
Immune markers including cytokines such as leukemia inhibitory factor, macrophage colony stimulating factor, interleukin - 1 beta, transforming growth factor beta-1, Tim-3, galectin-9 and other markers considered to play a role in implantation will also be measured.
Contact information is provided by the study sponsor or research team.
Hiu Tan Margaret Lee
CONTACT
Pui Wah Jacqueline Chung, MBBS
CONTACT
Chinese University of Hong Kong
Other
Transcriptome Profiling and Immune/ Biochemical Markers of Peripheral Blood to Predict Endometrial Receptivity and Successful Implantation
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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