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NCT Number: NCT00985049

TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)

Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small pieces of heart tissue from patients undergoing heart surgery before and after this period of ischemia. This will be compared to blood gene expression in blood cells and analyzed with the patients' genetic profile. This might allow us to assess the amount of inflammation that occurs when patients are on the heart-lung machine as well as examine the effects genes have on this critical time period.

Recruiting

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Key information

Conditions

Cardiovascular Diseases

Age range

20 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States

Location status: Recruiting

Location contact

Sergey Karamnov, MD

CONTACT

[email protected]

Sergey Karamnov, MD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged greater than 20 years
  • Undergoing aortic valve surgery with or without CABG surgery
  • Receive and apical vent as part of the surgery

Exclusion criteria

  • Will not receive an apical left ventricular vent

Treatment and study plan

Primary outcomes

  1. Differential gene expression

    Time frame: Immediate

Study contacts

Contact information is provided by the study sponsor or research team.

Jochen D Muehlschlegel, MD, MMSc, MBA

CONTACT

[email protected]

4109558408

Sponsors and collaborators

Lead sponsor

Brigham and Women's Hospital

Other

Collaborators

  • American Heart Association
  • Harvard Medical School (HMS and HSDM)
  • National Heart, Lung, and Blood Institute (NHLBI)

Registry information

Official study title

Whole Genome Expression of Left Ventricular Myocardium During Cardiac Surgery

Important dates

Study start
2009
Primary completion
2025
Study completion
2025
First posted
Sep 28, 2009
Registry last updated
Aug 22, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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