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Completed

NCT Number: NCT02236767

Transcranial Magnetic Stimulation Treatment of Hoarding Disorder

This is multiple baseline study including up to three participants with a primary diagnosis of hoarding disorder. All patients will receive unblinded repetitive transcranial magnetic stimulation study intervention.

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Key information

Conditions

Hoarding Behavior

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hartford Hospital

Hartford, Connecticut, 06106, United States

About this study

Study assessments will be conducted at pre-baseline, weekly during baseline assessment (until a stable baseline is established, but not less than 2, 4, and 6 weeks for patients respectively), weekly during treatment, and at post-treatment. Magnetic resonance imaging (MRI) will be competed at pre-baseline, pre-treatment, and post-treatment. Treatment will entail daily (5 days/week) sessions of repetitive transcranial magnetic stimulation using the Neurostar Therapy System for 6 weeks employing right-sided, low frequency stimulation (1 Hz, 900 pulses/session for 30 sessions, 27,000 total pulses, intensity at 90% of the passive motor threshold) to the dorsolateral prefrontal cortex (DLPFC). Neuronavigation will direct coil placement over the DLPFC based upon structural MRI.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed with hoarding disorder as primary disorder
  • Clinical Global Impression Score > 3
  • Saving Inventory-Revised score > 39

Exclusion criteria

  • Any contraindication for participation in magnetic resonance imaging or transcranial magnetic stimulation
  • Severe and/or unstable medical or psychiatric condition that require immediate medical attention
  • Diagnosed with current major depressive episode
  • Currently taking psychiatric medication

Treatment and study plan

Neurostar Transcranial Magnetic Stimulation Therapy System

Device

Treatment will entail daily (5 days/week) sessions of repetitive transcranial magnetic stimulation for 6 weeks employing right-sided, low frequency stimulation (1 Hz, 900 pulses/session for 30 sessions, 27,000 total pulses, intensity at 90% of the passive motor threshold) to the dorsolateral prefrontal cortex (DLPFC).

Primary outcomes

  1. The Saving Inventory-Revised (SI-R) Total Score

    Time frame: Pre-baseline, Post-baseline/Pre-treatment, Post-treatment, 2-Month Follow-up

    The Saving Inventory-Revised (SI-R) is a self-report measure which includes 23 items assessing the severity of hoarding symptoms including difficulty discarding, acquiring, and clutter. The 23 items are added for a total score which ranges from 0 to 92 and with higher score indicating more severe hoarding symptoms.

Sponsors and collaborators

Lead sponsor

Hartford Hospital

Other

Collaborators

  • Neuronetics

Registry information

Important dates

Study start
2014
Primary completion
2014
Study completion
2014
First posted
Sep 11, 2014
Registry last updated
Oct 6, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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