Department of Psychiatry, Charles University in Prague and General University Hospital in Prague
Prague, 121 08, Czechia
NCT Number: NCT03273205
Anorexia Nervosa (AN) is a serious and often chronical eating disorder characterized by an extreme effort for weight loss and intense fear of becoming fat despite the obvious thinness. The treatment is very difficult and not always effective. That´s the reason why we are looking for new ways of the therapeutic approach.
Transcranial direct current stimulation (tDCS) is a neuromodulation technique, which modulates the neuronal excitability. According to previous research it has a potential to help people with Anorexia Nervosa.
The device for the tDCS has two electrodes, an anode (the excitatory one) and a cathode (the inhibitory one). We put them on the skull into the different positions, in dependence on the fact, if we want to excite or on to inhibit the parts of the brain under the electrodes.
There are several hypothesis how could the tDCS help in patients with AN. One of them speaks about the hyperactivity of the right hemisphere in Anorexia Nervosa. Therefore could the anodal (excitatory) tDCS over the left hemisphere and the cathodal (inhibitory one) help in resetting the inter-hemispheric balance.
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Notify Me18 year–65 year
All sexes
Interventional
Not applicable
Prague, 121 08, Czechia
Stimulation of 2 milliampere is applied for 30 minutes in every real session. Together there are 10 sessions, the application is every workday within 2 weeks.
All measurements and questionnaires are made 4 times:
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
This group gets a real stimulation
This group gets a sham stimulation
Time frame: 8 weeks
Comparison of the total scores and subscores of the Eating Disorders Examination Questionnaire (EDEq)
Time frame: 8 weeks
Comparison of the total scores of the Zung Self-Rating Depression Scale
Time frame: 8 weeks
Measurement of the pain threshold with the TSA II Neuro Sensory Analyzer
Time frame: 8 weeks
Regularly weighting on the scale
Silvie Ceresnakova
Other
The Changes in the Body-perception and Perception of the Pain in Patients With Anorexia Nervosa Before and After Using the tDCS
Acronym: SANO
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