Skip to main content
OpenTrials
Completed

NCT Number: NCT03273205

Transcranial Direct Current Stimulation (tDCS) in the Treatment of Anorexia Nervosa

Anorexia Nervosa (AN) is a serious and often chronical eating disorder characterized by an extreme effort for weight loss and intense fear of becoming fat despite the obvious thinness. The treatment is very difficult and not always effective. That´s the reason why we are looking for new ways of the therapeutic approach.

Transcranial direct current stimulation (tDCS) is a neuromodulation technique, which modulates the neuronal excitability. According to previous research it has a potential to help people with Anorexia Nervosa.

The device for the tDCS has two electrodes, an anode (the excitatory one) and a cathode (the inhibitory one). We put them on the skull into the different positions, in dependence on the fact, if we want to excite or on to inhibit the parts of the brain under the electrodes.

There are several hypothesis how could the tDCS help in patients with AN. One of them speaks about the hyperactivity of the right hemisphere in Anorexia Nervosa. Therefore could the anodal (excitatory) tDCS over the left hemisphere and the cathodal (inhibitory one) help in resetting the inter-hemispheric balance.

Completed

Looking for future studies?

Notify Me

Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Psychiatry, Charles University in Prague and General University Hospital in Prague

Prague, 121 08, Czechia

About this study

Stimulation of 2 milliampere is applied for 30 minutes in every real session. Together there are 10 sessions, the application is every workday within 2 weeks.

All measurements and questionnaires are made 4 times:

  • Before the stimulation
  • On the day of the last stimulation
  • 14 days after the last stimulation
  • 28 days after the last stimulation

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with the diagnosis of anorexia nervosa

Exclusion criteria

  • patients: with the diagnosis of epilepsy, after a serious injury of head, with chronic headache, with some metal or electronic implants in their heads and patients who are pregnant.

Treatment and study plan

Anodal tDCS

Device

This group gets a real stimulation

Sham tDCS

Device

This group gets a sham stimulation

Primary outcomes

  1. Change of the Eating Disorders Examination Questionnaire (EDEq) score

    Time frame: 8 weeks

    Comparison of the total scores and subscores of the Eating Disorders Examination Questionnaire (EDEq)

Secondary outcomes

  1. Change of the Zung Self-Rating Depression Scale

    Time frame: 8 weeks

    Comparison of the total scores of the Zung Self-Rating Depression Scale

  2. Change of the pain threshold

    Time frame: 8 weeks

    Measurement of the pain threshold with the TSA II Neuro Sensory Analyzer

  3. Change of the weight in kilograms

    Time frame: 8 weeks

    Regularly weighting on the scale

Sponsors and collaborators

Lead sponsor

Silvie Ceresnakova

Other

Registry information

Official study title

The Changes in the Body-perception and Perception of the Pain in Patients With Anorexia Nervosa Before and After Using the tDCS

Acronym: SANO

Important dates

Study start
2017
Primary completion
2020
Study completion
2021
First posted
Sep 6, 2017
Registry last updated
Feb 17, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.