Transcranial Direct Current Electrical Stimulation (tDCS) in Drug-resistant Epilepsy

Inclusion criteria

• - Age: Older than 12 years old
• Patients with drug-resistant focal epilepsy with no surgical indication or with a previous surgical failure or refusing surgery.
• SEEG previously performed before inclusion with an adequate definition of the epileptogenic zone
• A clinical or research MRI scan that is suitable for navigated brain stimulation (NBS) and definition of target area.
• Number of seizures >3/month during the baseline (before the first session of tDCS treatment), for at least 3 months
• Have stable medications for the whole study duration and few weeks before
• Total IQ>65
• Be able to understand, speak and write in French
• Patient, parents or legally representative who have given written informed consent to allow the study data collection procedures,
• Be a beneficiary of affiliated to a health insurance plan

Exclusion criteria

• - Generalized epilepsy
• Presenting contraindication to MRI, a serious intercurrent pathology, a progressive brain tumor
• Skin conditions (e.g., eczema, lesion)
• Any cranial metal implants (excluding <1 mm thick epicranial titanium skull plates and dental fillings) or medical devices (i.e. cardiac pacemaker, deep brain stimulator, medication infusion pump, cochlear implant).
• Previous surgeries opening the skull leaving skull defects capable of allowing the insertion of a cylinder with a radius greater or equal to 5 mm.
• Metal inside the head (outside the mouth) such as shrapnel, surgical clips
• Patient currently participating in another clinical trial or having participated in a clinical trial in the month prior to inclusion.
• Any condition that makes the study subject, in the opinion of the investigator, unsuitable for the study.
• Person protected by articles L1121-5, L1121-6 and L1121-8 of Public Health Code (pregnant or breastfeeding woman, deprived of liberty by judicial decision, situations of social fragility, adults unable or unable to express their consent).