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NCT Number: NCT06740968

Transcranial Alternating Current Stimulation (tACS) in Stuttering

The purpose of this study is to investigate how mild, noninvasive electrical brain stimulation affects speech relevant brain areas, which may in turn affect speech fluency and speaking-related brain activity in people that stutter. The long-term goal of this study is to test the therapeutic potential of transcranial alternating current stimulation (tACS) for the treatment of stuttering.

The study team hypothesizes that if stuttering involves impaired initiation of motor programs, delta-tuned tACS will strengthen communication between brain regions and decrease stuttering. Therefore, delta-tuned sensorimotor tACS will be paired with fluency-induced speech (choral reading), which is hypothesized to decrease stuttering via improved auditory motor integration.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Michigan

Ann Arbor, Michigan, 48109, United States

Location status: Recruiting

Location contact

Soo-Eun Chang, PhD

CONTACT

[email protected]

734-232-0300

Soo-Eun Chang, PhD

PRINCIPAL_INVESTIGATOR

About this study

Participants will have screening and baseline visits that include a variety of tests and procedures (i.e. standardized tests of speech, language, hearing test, music training questionnaire, working memory tests, and speech sample to characterize stuttering, magnetic resonance imaging (MRI) and electroencephalography (EEG)). Following these, participants will have 3 sessions (active and sham conditions) and then a one month follow-up phone or video call.

Of note, there will be an embedded pilot study to refine the experimental protocol in terms of practicality and feasibility and these participants will not be included in this registration. The only purpose of this embedded study is to refine the protocol and it does not have any health or behavioral outcomes.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

for stutterers:

  • Have normal language, hearing, and cognition
  • Speak English as the primary language
  • Currently stutter
  • Score (per protocol) a certain value on the Stuttering Severity Instrument (SSI-4).
  • Have not received any treatment for stuttering within the past year

Exclusion criteria

for stutterers:

  • History of seizures
  • Major medical or neurological illness (e.g., stroke, serious head trauma, brain infection, Parkinson's disease, etc.)
  • History of closed head injury with loss of consciousness (e.g., concussion)
  • Metal or electronic implants such as cochlear implants and pacemakers anywhere in the body
  • Braids or other hair styling that prevents direct access to the scalp (if removal not possible)
  • Currently pregnant

Treatment and study plan

transcranial alternating current stimulation (tACS)

Device

During each of the 3 stimulation visits, participants will be seated in a comfortable position and a cap will be placed on participant's head similar to a swimming cap. Small electrodes will be placed near the surface of the scalp at certain regions of interest, and a weak electrical current will be passed through the electrodes into speech related brain areas for 20 minutes. The study team will not use current strengths exceeding 2 milliamps (mA).

Primary outcomes

  1. Change in Phase Synchronization

    Time frame: Baseline (pre-tACS), approximately 3 hours (post-tACS) (visits 3-5)

    The study will compare EEG data recorded before and after stimulation to determine if tACS contributed to any changes. This will be measured by Phase Locking Value (PLV; measured from 0 to 1) between the two regions targeted by stimulation calculated as [pre(active-sham)] - [post(active-sham)] at each tACS visit.

Secondary outcomes

  1. Percentage of stuttered syllables produced during speech sample

    Time frame: Baseline (before tACS), approximately 3 hours (post-tACS) (visits 3-5)

    The study will calculate the percentage of stuttered syllables (out of total syllables) in a speech sample. Decreased stuttered syllables represents better outcomes (greater reduction in stuttering).

Other outcomes

  1. Percent change in perturbation response

    Time frame: Baseline (before tACS), approximately 3 hours (post-tACS) (visits 3-5)

    The study will compare the perturbation task from before and after tACS. This is measured by the percent change in perturbation response.

  2. Change in Phase Amplitude Coupling

    Time frame: Baseline (before tACS), approximately 3 hours (post-tACS) (visits 3-5)

    The study will compare EEG data recorded before and after stimulation to determine if tACS contributed to any changes. Phase Amplitude Coupling (PAC) will be calculated within and between the two regions targeted by stimulation calculated as [pre(active-sham)] - [post(active-sham)] at each tACS visit.

Study contacts

Contact information is provided by the study sponsor or research team.

Emily Garnett, PhD

CONTACT

[email protected]

734-232-3371

Soo-Eun Chang, PhD

CONTACT

[email protected]

734-232-0300

Sponsors and collaborators

Lead sponsor

University of Michigan

Other

Registry information

Official study title

Improving Neural Oscillation and Synchrony Between Motor and Auditory Regions in Stuttering Using Personalized Transcranial Alternating Current Stimulation (tACS)

Important dates

Study start
2025
Primary completion
2029
Study completion
2029
First posted
Dec 18, 2024
Registry last updated
Sep 12, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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