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OpenTrials
Completed

NCT Number: NCT02554539

Transciptomic Modification Induced by miRNAs in Endometrial Fluid

The purpose of this study is to understand the mechanism of communication between the uterine environment and the preimplantation human embryo. The investigators are interested in understanding how the in-utero environment during the window of implantation is different in normal weight and overweight/obese women and how this may impact the programming of the developing embryo.

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Key information

Conditions

MicroRNA in Endometrial Fluid

Age range

21 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Stanford University

Stanford, California, 94304, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Meet the WHO criteria for normal weight (BMI < 25) and overweight/obese (BMI > 25)
  • Age 21-45

Exclusion criteria

  • Age < 21 or > 45
  • Women with history of hysterectomy

Treatment and study plan

Endometrial fluid aspiration

Procedure

Patient will undergo a biopsy to aspirate endometrial fluid from the uterine cavity

Primary outcomes

  1. Gene expression profile in human embryos

    Time frame: Samples will be collected within 1 month of enrollment

    We will perform RNA sequencing on the human embryo to quantify which genes are up and down regulated in obese compared to normal weight controls.

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Registry information

Official study title

Human Embryonic Transciptomic Modification Induced by miRNAs Secreted by Human Endometrium to Endometrial Fluid

Acronym: miRNA_EF

Important dates

Study start
2015
Primary completion
2017
Study completion
2017
First posted
Sep 18, 2015
Registry last updated
Apr 20, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.