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Completed

NCT Number: NCT03215290

Trans-parenchymal Compressing Suture in Major Liver Resection

Non-anatomical liver resection with appropriate resection margin was regarded as a potential curative treatment for selected major hepatic carcinoma due to preserving maximal normal liver, especially in cirrhotic patients. But occurrence of cutting surface related complications become a main challenge.

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Key information

Conditions

Liver Carcinoma Resectable

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

In order to better manage the cutting surface after liver resection, we further applied trans-parenchymal compressing suture to "not good" cutting surface in hope of decreasing cutting surface related complication. A majority of studies investigating cutting surface management are limited to non-surgical treatments, such as the application of hemostasis agents including fibrin sealants, oxidized cellulose, and absorbable gelatin sponge13-15 . But there is no consensus regarding the necessity of the hemostatic agent application to the liver cutting surface. Up to date, few studies investigate surgical suture management of the cutting surface in liver resection.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • tumor size more than 5cm
  • non-anatomical liver resection;

Exclusion criteria

  • intravascular infiltration with tumor embolus;
  • previous liver surgical treatment (e.g. microwave ablation; preoperative transcatheter arterial chemoembolization (TACE);
  • other concomitant extrahepatic procedures (e.g. splenectomy).
  • exposed Glisson Shealth, main hepatic veins or (and) retro-hepatic inferior vena cava.

Treatment and study plan

TCS

Procedure

The cutting surface recognized as "not good" cutting surface was further trans-parenchymal compressing sutured, if possible, using a hepatic needle.

Other names: trans-parenchymal compressing suture

Primary outcomes

  1. Cutting surface related complications

    Time frame: 90 days

    After liver resection, some complication related cutting surface may occur, including surgery site infection, bile leakage, bleeding.

Secondary outcomes

  1. Interventions for cutting surface related complications

    Time frame: 90 days

    Once the cutting surface related complications occur, some interventions need to be performed to treat these complications, such as percutaneous abdominal paracentesis or reoperation.

Sponsors and collaborators

Lead sponsor

Tongji Hospital

Other

Registry information

Official study title

Application of Trans-parenchymal Compressing Suture in Major Liver Resection to Decrease Cutting Surface Related Complication.

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Jul 12, 2017
Registry last updated
Jul 12, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.