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OpenTrials
Completed

NCT Number: NCT07013812

Tranexamic Acid to Reduce Blood Loss in Women Having Planned Cesarean Section

This clinical trial was done to find out if tranexamic acid (TXA) can safely reduce the amount of blood loss during cesarean (C-section) deliveries. Heavy bleeding is a major risk during childbirth, especially in C-sections, and can be life-threatening.

The main question this study wanted to answer was:

Does giving tranexamic acid before surgery reduce the amount of blood lost during a planned C-section?

In this study, 68 women who were scheduled for elective (planned) C-section deliveries were randomly assigned to receive either tranexamic acid or a placebo (a look-alike substance with no medicine in it) before surgery. The medication was given by slow injection just 15 minutes before the operation.

All surgeries followed the same procedure and were done by experienced obstetric surgeons. The amount of blood lost during surgery was carefully measured and compared between the two groups.

The goal was to find a simple and safe way to lower the risk of blood loss and its complications during C-sections, improving outcomes for mothers.

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Key information

Conditions

Cesarean Section Blood Loss During Surgery

Age range

20 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Combined Military Hospital

Multan, Punjab Province, 60000, Pakistan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Women age 20-45 years
  • at 37-40 weeks of gestation (on LMP)
  • Planned to undergo cesarean section under spinal anesthesia

Exclusion criteria

  • Women with previous history of thromboembolic events
  • Allergy to tranexamic acid
  • Women with morbidly adherent placenta (on antenatal USG)

Treatment and study plan

Tranexamic Acid (IV)

Drug

One gram (10 ml) intravenous injection

Other names: TXA, Cyklokapron, Lysteda, Transamin.

Dextrose 5% (D5W)

Drug

5% dextrose water intravenously

Primary outcomes

  1. Blood Loss

    Time frame: During the elective cesarean section procedure

    Intraoperative blood loss (ml) was measured by taking weight difference of the dressings and towels before and after the operation plus blood added to the fluid volume inside the suction apparatus.

Sponsors and collaborators

Lead sponsor

Combined Military Hospital Multan

Other

Registry information

Official study title

Role of Tranexamic Acid in Control of Intraoperative Blood Loss in Women Undergoing Elective Cesarean Section

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Jun 10, 2025
Registry last updated
Jun 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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