Tranexamic Acid in Preventing Postpartum Hemorrhage in High Risk Pregnancies During Elective Cesarean Section

postpartum hemorrhage (PPT) represents one of the major causes of maternal mortality . Tranexamic acid is used in many studies in management of PPH in combination with ecobolics. this study aims to evaluate the possible value of the use of tranexamic acid in prevention of postpartum hemorrhage .

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Key information

Conditions

Postpartum Hemorrhage Female Urogenital Diseases and Pregnancy Complications Hemorrhage Obstetric Labor Complications Pathologic Processes Pathological Conditions, Signs and Symptoms Pregnancy Complications Puerperal Disorders Urogenital Diseases Uterine Hemorrhage

Age range

20 year–42 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 2 / Phase 3

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Gestational age of 28 weeks or more.
Chronic Hypertension.
Preeclapmsia -Eclampsia.
Multiple pregnancy.
Uterine Liomyomas.
Polyhydraminos.
Fetal macrosomia.
Associated Thrombocytopenia
History of postpartum hemorrhage.

Exclusion criteria

Patients with rheumatic heart disease.
Patients with history Cardiac Valve Replacement.
Current or past history of DVT.
Women on any anticoagulant therapy.
Sensitivity to tranexamic acid
Pregnancies with any abnormally implanted or located placenta.

Treatment and study plan

Tranexamic Acid

Drug

Tranexamic acid (Kepron, Amoun, Egypt) was given slowly intravenously over 10 minutes just before the skin incision of elective cesarean section to group A. Tranexamic acid injection was prepared by diluting 1g (10 mL) tranexamic acid into 20 ml of 5% glucose.

Primary outcomes

prevention of postpartum hemorrhage in high risk group

Time frame: intraoperative

assessment of intraoperative blood loss

Sponsors and collaborators

Lead sponsor

Mansoura University

Other

Registry information

Official study title

The Effect of Tranexamic Acid in Preventing Postpartum Hemorrhage in High Risk Pregnancies During Elective Cesarean Section, a Randomized Controlled Clinical Trial

Important dates

Study start: 2016
Primary completion: 2017
Study completion: 2017
First posted: Nov 24, 2017
Registry last updated: Nov 27, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed