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Completed

NCT Number: NCT02682888

Trait Anxiety and Defensive Networks

to examine the association between trait and defensive network connectivity and the modulatory effect of oxytocin on it

Completed

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Key information

Conditions

Healthy

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

school of life science and technology, University of Electronic Science and Technology of China

Chengdu, Sichuan, 610054, China

About this study

Individuals with high trait anxiety show stable anxiety proneness even in the absence of real threat, which could be a result of intrinsic hyper-connectivity in the defensive systems. In the present study, healthy subjects' trait anxiety levels will be assessed by the sub-trait inventory of the State-Trait Anxiety Inventory. Then two experiments using resting-state fMRI technique will be conducted to first map how hubs in the defensive systems organized in high anxious individuals in a stimuli-free situation (Experiment 1) and then we will examine the modulatory effect of the intranasal administration of oxytocin on functional connectivity in these independently defined defensive networks (Experiment 2).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy subjects without past or current psychiatric or neurological disorders

Exclusion criteria

  • females should not be pregnant or during menstruation.

Treatment and study plan

trait anxiety scale

Behavioral

splitting subjects into 2 groups according to scores of the trait anxiety scale

Oxytocin

Drug

intranasal administration of oxytocin

Placebo

Drug

intranasal administration of placebo

Primary outcomes

  1. the resting state functional connectivity changes in the defensive network

    Time frame: one day

    The resting-state activity can be accessed using functional magnetic resonance imaging (fMRI) by measuring spontaneous and low-frequency fluctuations (< 0.1 Hz) when the brain is at rest. Group differences will be calculated in the high trait anxiety group relative to the low trait anxiety group and in the oxytocin group relative to the placebo group.

Sponsors and collaborators

Lead sponsor

University of Electronic Science and Technology of China

Other

Registry information

Official study title

Trait Anxiety Modulates Resting State Functional Connectivity of Defensive Networks

Important dates

Study start
2015
Primary completion
2021
Study completion
2021
First posted
Feb 17, 2016
Registry last updated
Feb 11, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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