Toxicogenomic and Immunocytotoxic Effects of Propofol and Isoflurane Anesthetics in Patients Undergoing Elective Surgery

The purpose of this study is to evaluate if the anesthetics propofol and isoflurane can damage DNA, induce apoptosis, change expression of genes related to apoptosis and DNA repair and change cytokines profile in patients submitted to elective surgery.

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Key information

Conditions

Patients in Good Health DNA Damage Types of General Anesthesia

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Botucatu Medical School, UNESP

Botucatu, São Paulo, 18618-000, Brazil

About this study

It is expected that the results provide relevant information to understand the possible adverse effects of anesthetics and contribute to the establishment of strategies aimed at reducing the risks to exposed individuals.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients in good health American Society of Anesthesia status physical I
elective minor surgery
general anesthesia

Exclusion criteria

smokers
alcoholics
previous medication or radiation

Treatment and study plan

Comparison of two anesthetic drugs

Drug

Isoflurane 1,0 minimum alveolar concentration Propofol 2mg/kg and 4ug/ml

Other names: Diprivan, Isoflurane

Primary outcomes

Evaluation of genotoxicity, gene expression, apoptosis and cytokines profile

Time frame: within 1 day after surgery

Sponsors and collaborators

Lead sponsor

UPECLIN HC FM Botucatu Unesp

Other

Collaborators

Fundação de Amparo à Pesquisa do Estado de São Paulo

Registry information

Important dates

Study start: 2008
Primary completion: 2009
Study completion: 2009
First posted: Mar 3, 2009
Registry last updated: Jan 6, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed