Skip to main content
OpenTrials
Completed

NCT Number: NCT00130143

Toxicities Associated With Subcutaneous Administration of Ethyol (Amifostine) for the Prevention of Radiation-Induced Toxicities

Dry mouth occurs very often in patients who receive radiation treatment. Amifostine is a drug approved to reduce the short and long-term occurrence of dry mouth when patients receive radiation treatment for head and neck cancer. Some studies have shown that Amifostine reduces the side effects of radiation treatment for lung cancer. The use of Amifostine is still being investigated in lung malignancies. Amifostine is found to be a protectant from radiation side effects of such normal tissues as bone marrow, skin, oral mucosal, esophagus, kidney and testes. Patients that receive radiation treatments for lung cancer may experience side effects involving the esophagus. It is hoped that patients will benefit from the protection of their esophagus and avoid delays in radiation treatment due to side effects of the radiation.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Head and Neck Cancer Head and Neck Neoplasms Lung Cancer Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The Dale & Frances Hughes Cancer Center

East Stroudsburg, Pennsylvania, 18301, United States

About this study

The protective capacity of thio-containing compounds against normal tissue damage from radiation have been recognized for over 40 years..

Although intravenous administration is the approved standard route, because of practical advantages there has been increasing interest in the subcutaneous administration of Ethyol, which presents multiple advantages when used for radioprotection.

Based on the data that has been presented, as well as the personal experience of this and other physicians/centers with subcutaneous administration of amifostine, the researchers are proposing an open-label study evaluating the rate and severity of toxicities associated with this route of administration. Toxicities to be assessed include nausea/vomiting, hypotension, and skin/fever reactions.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient is eligible to receive subcutaneous amifostine under site's current practice guidelines for radioprotection.
  • Eastern Cooperative Oncology Group (ECOG) performance status < 2
  • Age > 18
  • Patient receiving radiation therapy or combined modality therapy to treat malignancy.
  • No evidence of distant metastatic disease.
  • Granulocyte count (segs & bands) > 2000/mm3 and platelet count > 100,000/mm3
  • Serum creatinine <2.0mg/dL
  • Total bilirubin <2.0mg%, SGOT < times the upper limit of normal.
  • Patients may not be entered on investigational therapeutic trials.
  • Patients or guardians must be informed of and understand the investigational nature of this study and give written informed consent prior to any study procedures.

Exclusion criteria

  • Life expectancy of <6 months
  • Patients receiving only chemotherapy to treat malignancy.
  • Patients who have been treated with any investigational drugs <4 weeks prior to study entry.
  • General medical or psychological conditions which would not permit the patient to complete the study or sign the informed consent.
  • Pregnancy; Women of childbearing potential should use an effective (for them) method of birth control throughout their participation in this study.
  • Patients who are currently receiving or have received amifostine for radioprotection within the prior 6 months are excluded.

Treatment and study plan

Ethyol (Amifostine)

Drug

Primary outcomes

  1. Primary endpoint: To evaluate how amifostine is given subcutaneously at each institution

  2. To determine treatment related toxicities and safety of subcutaneous administration of amifostine for the prevention of radiation-induced toxicities

Secondary outcomes

  1. Secondary endpoints: Evaluate efficacy of amifostine in reducing radiation induced toxicities in these patients

Sponsors and collaborators

Lead sponsor

The Dale & Frances Hughes Cancer Center

Other

Collaborators

  • MedImmune LLC

Registry information

Official study title

Open-Label Prospective Trial Evaluating the Toxicities Associated With Subcutaneous Administration of Ethyol (Amifostine) for the Prevention of Radiation-Induced Toxicities

Important dates

Study start
2003
Study completion
2004
First posted
Aug 15, 2005
Registry last updated
Sep 27, 2005

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.