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Recruiting

NCT Number: NCT07236892

Towards Restoring Complex Movement After Paralysis: Algorithm Development With Healthy Participants

Participants will perform experiments with non-invasive activity recordings. The study will record from multiple non-invasive signal sources that reflect motor intent that may include: electroencephalography (EEG), electromyography (EMG), functional near infrared spectroscopy (fNIRS), inertial measurement units (IMUs), eye movements, pupil size, and speech. Participants will wear all or a subset of these sensors and be asked to perform, imagine, or attempt movements or speech. The recorded sensor signals will be decoded to help guide an end effector, which may be a computer, robotic arm, wheelchair, or other assistive device.

These experiments present minimal risk and participants may withdraw participation at any time for any reason. Participants may return for additional experiments if desired and to perform additional comparisons. If a participant withdraws during a comparison, another participant will be recruited to complete collection of data for that comparison.

Recruiting

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Key information

Conditions

Movement Disorders Central Nervous System Diseases Nervous System Diseases Neurorehabilitation Non-invasive Activity Recording

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

UCLA Neural Engineering and Computation Lab

Los Angeles, California, 90095, United States

Location status: Recruiting

Location contact

Restoring Movement Study Coordinator

CONTACT

[email protected]

310-983-3068

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Fluent in the English language

Exclusion criteria

  • Neurological injury or disease that results in functional paralysis

Treatment and study plan

Participants will perform experimental tasks while undergoing non-invasive activity recordings, which may include EEG, EMG, IMUs, fNIRS, eye gaze, or pupillometry.

Behavioral

Participants may be prompted to imagine, attempt, or perform actions while a task is being performed on a computer, robotic arm, wheelchair, or exoskeleton. Participants may also autonomously perform actions to control each end effector. Participants may be asked to control a cursor to acquire a target or multiple targets. Participants may be asked to pick and place various objects, interact with articulated objects, or perform other motor tasks using a robotic manipulator. Participants may be asked to navigate a wheelchair.

Primary outcomes

  1. Normalized Performance

    Time frame: Usually one visit (Day 1), with possible additional study visits usually within a month.

    The normalized performance of the non-invasive assistive interface on a task. Non-invasive signals, which may include electroencephalography, electromyography, functional near infrared spectroscopy, inertial measurements units, eye movements, pupil size, and speech are input into an algorithm that controls an end effector's movements. The end effector, which may be a computer cursor, robotic manipulator, wheelchair, or other assistive device, is used to perform a motor task. The normalized performance is derived from the the performance of the end effector on the motor task, reflecting the overall performance of the non-invasive assistive interface. The minimum value is zero. There is no maximum value, although the values are usually less than 1. Higher is better.

Study contacts

Contact information is provided by the study sponsor or research team.

Restoring Movement Study Coordinator

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

University of California, Los Angeles

Other

Collaborators

  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Registry information

Official study title

Restoring Complex Movement and Locomotion After Paralysis Through Collaborative Copilots: Algorithm Development With Healthy Participants

Important dates

Study start
2025
Primary completion
2029
Study completion
2029
First posted
Nov 19, 2025
Registry last updated
Dec 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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