Total Laparoscopic vs Open Pancreaticoduodenectomy for the Treatment of Periampullary Adenocarcinomas

Laparoscopic pancreaticoduodenectomy (LPD), a surgical option for nonpancreatic periampullary adenocarcinoma (NPPA), is a complex procedure that has become increasing popular. However, there is no consensus as to whether this technique should be performed routinely. Our aim was to evaluate the outcomes of LPD compared with open pancreaticoduodenectomy (OPD).

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Key information

Conditions

Periampullary Carcinoma

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Theodor Bilharz Research Institute

Giza, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

• Body mass index <28.0 kg/m2.

Ampullary tumors, duodenal tumors restricted to the second part of the duodenum, or lower common bile duct tumors.
Carefully confirmed resectability of the tumors based on preoperative radiology conducted by experienced radiologists and surgeons.

Exclusion criteria

• Patients with >180 degrees superior mesenteric artery encasement

Any celiac abutment.
Unreconstructable superior mesenteric vein/portal occlusion" Aortic invasion or encasement.
A history of previous upper abdominal surgery.
Tumors extending to the uncinate.
Severe cardiorespiratory comorbidities.

Treatment and study plan

Conventional open pancreaticoduedectomy

Procedure

Fifteen patients in Group A had a traditional open pancreaticoduedectomy.

Total laparoscopic pancreaticoduedectomy

Procedure

Fifteen patients in Group A had a total laparoscopic pancreaticoduedectomy.

Primary outcomes

The incidence of pancreatic fistula after laparoscopic pancreaticoduodenectomy in comparison to open surgery

Time frame: in 2 years between 2023 - 2025

Laparoscopic pancreaticoduodenectomy is a complex procedure that has become increasing popular. However, there is no consensus as to whether this technique should be performed routinely.

Our aim was to evaluate the outcomes of Laparoscopic pancreaticoduodenectomy compared with open pancreaticoduodenectomy.

Sponsors and collaborators

Lead sponsor

Theodor Bilharz Research Institute

Other

Registry information

Important dates

Study start: 2023
Primary completion: 2025
Study completion: 2025
First posted: Feb 4, 2026
Registry last updated: Feb 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed