Topical Oestrogens and Antimuscarinics In The Treatment Of Detrusor Overactivity

Despite the great number of reports about the efficacy of oestrogens or antimuscarinics on OAB symptoms, so far no author has tried to investigate whether the concomitant administration of these two drugs, acting on two different pathophysiological mechanisms, could have a synergic effect reducing the rate of non-responders to treatment.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Overactive Bladder Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Lower Urinary Tract Symptoms Male Urogenital Diseases Pathological Conditions, Signs and Symptoms Signs and Symptoms Urinary Bladder Diseases Urinary Bladder, Overactive Urogenital Diseases Urologic Diseases Urological Manifestations

Sex eligibility

Female

Study type

Interventional

Phase

Phase 2 / Phase 3

Primary location

Department of Gynecology and Obstetrics - Università dell'Insubria

Varese, 21100, Italy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All post-menopausal women with symptoms of overactive bladder and urodynamically proven pure detrusor overactivity

Exclusion criteria

concomitant urodynamic stress incontinence
documented recurrent urinary tract infections
previous antimuscarinic treatment
previous pelvic surgery
concomitant systemic HRT
history of breast or endometrial cancer
neurological disease
clinical contraindications to treatment with oestrogen or antimuscarinics
patients included in other ongoing clinical trials

Treatment and study plan

Tolterodine 4 mg

Drug

arm 2: Tolterodine 4 mg + local oestrogens once daily for 12 weeks

Drug

Sponsors and collaborators

Lead sponsor

Università degli Studi dell'Insubria

Other

Registry information

Official study title

Is There A Synergic Effect Of Topical Oestrogens When Associated To Antimuscarinics In The Treatment Of Symptomatic Detrusor Overactivity

Important dates

Study start: 2004
Study completion: 2007
First posted: Apr 1, 2008
Registry last updated: Apr 1, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed