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Completed

NCT Number: NCT03223350

Topical Capsaicin for Cyclical Vomiting

This is a phase 2 randomized controlled trial testing the effect of topical capsaicin for the relieve of nausea and vomiting.

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Key information

Conditions

Cyclical Vomiting Familial cyclic vomiting syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Henry Ford Hospital

Detroit, Michigan, 48202, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • suspected cyclical vomiting syndrome / cannabinoid hyperemesis
  • active severe nausea or vomiting in the emergency department

Exclusion criteria

  • pregnant women, children < 18 years, no prior history of similar symptoms, suspected surgical or infectious cause of symptoms, suspected hepatitis or pancreatitis, allergy to capsaicin or hot peppers, chronic use of prescription antiemetic in prior 24 hours, abdominal pain alone (without nausea or vomiting)

Treatment and study plan

Capsaicin 0.1% Cream

Drug

Topical application

Placebos

Drug

placebo cream

Primary outcomes

  1. Nausea Visual Analog Scale

    Time frame: 30 minutes

    Nausea visual analog scale, ranging from 0-100 mm, high measurement indicates worse nausea

Sponsors and collaborators

Lead sponsor

Henry Ford Health System

Other

Registry information

Official study title

Topical Capsaicin Cream for Treatment of Suspected Cyclical Vomiting Syndromes

Important dates

Study start
2017
Primary completion
2019
Study completion
2019
First posted
Jul 21, 2017
Registry last updated
Dec 15, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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