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Completed

NCT Number: NCT03130153

Topical Analgesic Versus Saline Mouth Rinses in Post Extraction Healing

There is no evidence based guidelines on using saline rinses for post extraction oral care among hypertensives. Similarly, benefit of orally dissolved topical analgesics in addition to orally administered analgesic is questionable.

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Key information

Conditions

Tooth Extraction Site Healing

Age range

20 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

Aga Khan University

Karachi, Sindh, 74800, Pakistan

About this study

Objective: To compare the post dental extraction healing among subjects who took simple analgesic tablets dissolved in water versus those who used saline rinses post operatively.

Methods: A study will be done among patients who underwent dental extractions at AKHSP dental clinic, Karachi, Pakistan. Carious, periodontally mobile, traumatized or broken down teeth among 20-70 years old in either gender will be included.

In addition to the routine prescription of antibiotics and oral analgesics, the hypertensive subjects (n=20) will be advised to take dissolved Aspirin tablet as an oral care while non-hypertensive will be divided into two sub groups (n=20 each), advised saline mouth rinses or dissolved Aspirin for 5 days, respectively.

The outcome (healing of the extraction socket) will be evaluated 7 days from the day of extraction on an ordinal scale.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Carious, periodontally mobile, traumatized or broken down teeth needing extraction
  • Age 20-70 years, both genders

Exclusion criteria

  • Diabetes
  • Osteoporosis, metabolic bone disease etc.
  • Radiation therapy or chemotherapy.

Treatment and study plan

Aspirin Powder

Drug

Aspirin powder to be dissolved in water and to be used as mouthwash twice daily for 7 days after tooth extraction.

Other names: Acetyl salicylic acid

normal saline

Drug

Normal saline to be used as mouthwash twice daily for 7 days after tooth extraction among non-hypertensive subjects.

Other names: 0.9% NaCl, Saline

Primary outcomes

  1. Healing of the extraction socket

    Time frame: Seven days from the day of extraction

    • = "healed or healing well"
    • = "incomplete healing but progressing"
    • = "poorly healed open margins and readily bleeding"

Sponsors and collaborators

Lead sponsor

Aga Khan University

Other

Registry information

Official study title

Comparison of Topical Analgesic With Saline Rinses in Post Extraction Healing Among Hypertensive and Non-Hypertensive Patients

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Apr 26, 2017
Registry last updated
Jun 28, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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