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Active, Not Recruiting

NCT Number: NCT05156580

Tongzhou Cohort Study

Long-term Impact of Overweight/Obesity and Hypertension on Cardiovascular Risk in Middle-aged and Elderly Adults

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Obesity Body Weight Cardiovascular Diseases Hypertension Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms Vascular Diseases

Age range

45 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Beijing Friendship Hospital, Capital Medical University

Beijing, Beijing Municipality, 100050, China

About this study

Overweight and obesity are major risk factors associated with the development of hypertension, poor blood pressure control, and adverse cardiovascular outcomes. However, evidence regarding the long-term impact of overweight/obesity and hypertension on cardiovascular risk in middle-aged and elderly populations remains limited. Therefore, the present study aims to evaluate the long-term effects of overweight/obesity and hypertension on cardiovascular risk in middle-aged and elderly adults.Additionally, a subgroup analysis will be conducted in participants with sarcopenia to assess the influence of blood pressure on prognosis, exploring potential interactions between muscle loss, hypertension, and cardiovascular outcomes.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Ages of ≥ 45 years
  • Participants from routine health examinations at Tongzhou Community Health Service Center
  • Availability for follow-up until 2026
  • No major barriers to provide written consent

Exclusion criteria

  • NA

Treatment and study plan

No intervention

Other

This is an observational study without any intervention

Primary outcomes

  1. Percentage of participants with major adverse cardiovascular events (MACEs)

    Time frame: 2021-2026

    Percentage of participants with major adverse cardiovascular events (MACEs), including all-cause death, nonfatal myocardial infarction (MI), nonfatal stroke and coronary revascularization.

Secondary outcomes

  1. Percentage of participants with all-cause death

    Time frame: 2021-2026

    Percentage of participants with cardiovascular, non-cardiovascular and undetermined death.

  2. Percentage of participants with MI

    Time frame: 2021-2026

    Percentage of participants with fatal and nonfatal MI.

  3. Percentage of participants with stroke

    Time frame: 2021-2026

    Percentage of participants with fatal and nonfatal stroke.

  4. Percentage of participants undergoing coronary revascularization

    Time frame: 2021-2026

    Percentage of participants undergoing ischemia- and non-ischemia-driven coronary revascularization.

  5. Change in BP control rate

    Time frame: 2021-2026

    Change in BP control rate (office BP: SBP < 140 mmHg and DBP < 90 mmHg) from baseline to follow-up.

  6. Change in SBP

    Time frame: 2021-2026

    Change in SBP from baseline to follow-up.

  7. Change in estimated glomerular filtration rate (eGFR)

    Time frame: 2021-2026

    Change in estimated glomerular filtration rate (eGFR) in ml/min/1.73m2 from baseline to follow-up.

  8. Change in low-density lipoprotein-cholesterol (LDL-c)

    Time frame: 2021-2026

    Change in low-density lipoprotein-cholesterol (LDL-c) in mmol/L from baseline to follow-up.

  9. Percentage of participants with Metabolic dysfunction-associated steatotic liver disease (MASLD)

    Time frame: 2021-2026

    Percentage of participants with Metabolic dysfunction-associated steatotic liver disease.

Sponsors and collaborators

Lead sponsor

Beijing Friendship Hospital

Other

Collaborators

  • Beijing Tongzhou Lucheng Community Health Service
  • Beijing Tongzhou Xuxinzhuang Community Health Service
  • Beijing Tongzhou Yongshun Community Health Service

Registry information

Official study title

Long-term Impact of Overweight/Obesity and Hypertension on Cardiovascular Risk in Middle-aged and Elderly Adults: A Cohort Study

Important dates

Study start
2016
Primary completion
2026
Study completion
2026
First posted
Dec 14, 2021
Registry last updated
Oct 2, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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