Tomography Positron Emission Assessment of the Impact of Cardiac Rehabilitation on Coronary Endothelial Function in Cardiac Failure

In patients with heart failure, the drive to the effort has demonstrated its safety and its interest. Patients with heart failure, endothelium-dependent peripheral vasodilatation is impaired by decreased activity of endothelial NO synthase. The rehabilitation training significantly improves peripheral endothelial function, and this improvement is correlated to the increase in exercise capacity. The impact on coronary endothelial function remains poorly documented, especially in non-ischemic dilated heart disease.

The main objective of this study is to investigate the effectiveness of cardiac rehabilitation on the restoration of coronary endothelial function in cardiac failure patient evaluated with Tomography Positron Emission 15O-H2O.

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Key information

Conditions

Cardiac Failure Cardiovascular Diseases Heart Diseases Heart Failure

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Service de Cardiologie

Caen, 14000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with heart failure with nonischemic dilated cardiomyopathy
Class II-III NYHA (New York Heart Association)
Having no contra-indication to the effort
Fraction Ejection ≤ 40%
patient who will have cardiac rehabilitation
Age over 18 years
informed consent signed
patient with a social security scheme

Exclusion criteria

Hypertension> 160/90 mmHg
High cholesterol level > 6.0 mmol / l
Diabetes known and treated
Active smoking
Valvular heart disease, congenital or ischemic
Pregnant or breastfeeding women
Age <18 years
Major Adult guardianship

Treatment and study plan

cardiac Rehabilitation

Procedure

Tomography Positron Emission

Other

Primary outcomes

Rate of myocardial blood flow during the cold test

Time frame: change over baseline and after 3 month

Sponsors and collaborators

Lead sponsor

University Hospital, Caen

Other

Registry information

Acronym: TEP-READ

Important dates

Study start: 2010
Primary completion: 2015
Study completion: 2015
First posted: Aug 17, 2015
Registry last updated: Mar 8, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed